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Ventricular Septal Defects (VSD)

The presence of a defect (opening) in the septum that separates the two ventricles of the heart. It can be congenital or acquired.

PubMed Health Glossary
(Source: NIH - National Cancer Institute)

About Ventricular Septal Defects (VSD)

A ventricular septal defect (VSD) is a hole in the part of the septum that separates the ventricles. (The ventricles are the lower chambers of the heart.)

A VSD allows oxygen-rich blood to flow from the left ventricle into the right ventricle, instead of flowing into the aorta as it should. So, instead of going to the body, the oxygen-rich blood is pumped back to the lungs, where it has just been.

An infant who is born with a VSD may have one or more holes in the wall that separates the two ventricles. The defect also may occur alone or with other congenital heart defects....Read more about Ventricular Septal Defects
NIH - National Heart, Lung, and Blood Institute

What works? Research summarized

Evidence reviews

Newborn screening for congenital heart defects: a systematic review and cost-effectiveness analysis

The objectives of this study were to provide evidence to inform policy decisions about the most appropriate newborn screening strategy for congenital heart defects and to identify priorities for future research that might reduce important uncertainties in the evidence base for such decisions.

Implantable cardioverter defibrillators for the treatment of arrhythmias and cardiac resynchronisation therapy for the treatment of heart failure: systematic review and economic evaluation

Study found that implantable cardiac defibrillators reduced all-cause mortality in people at increased risk of sudden cardiac death as a result of previous ventricular arrhythmias or cardiac arrest, remote myocardial infarction or ischaemic/non-ischaemic heart failure and LVEF ≤ 35%. Cardiac resynchronisation therapy reduced all-cause mortality and improved other outcomes in people with heart failure as a result of left ventricular systolic dysfunction and cardiac dyssynchrony when compared with optimal pharmacological therapy. The devices were cost-effective at a willingness-to-pay threshold of £30,000 when compared with optimal pharmacological therapy.

A systematic review on the efficacy and safety of transcatheter device closure of ventricular septal defects (VSD)

BACKGROUND: Advances in interventional techniques now allow for transcatheter treatment of some ventricular septal defects (VSD), although there remain concerns about adverse events. We performed a systematic review to look at outcomes and complications associated with transcatheter closure of VSD.

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Terms to know

Congenital Heart Defects (Congenital Heart Diseases)
Congenital heart defects are problems with the heart's structure that are present at birth.
The hollow, muscular organ that maintains the circulation of the blood.
Heart Ventricles
The lower right and left chambers of the heart.
Interventricular Septum
Interventricular septum is the stout wall separating the lower chambers (the ventricles) of the heart from one another.

More about Ventricular Septal Defects

Photo of a baby

Also called: Interventricular septal defects

Other terms to know: See all 4
Congenital Heart Defects (Congenital Heart Diseases), Heart, Heart Ventricles

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