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Uveitis

Inflammation of the middle layer of the eye, the uvea.

PubMed Health Glossary
(Source: Wiktionary)

About Uveitis

Uveitis is a general term describing a group of inflammatory diseases that produces swelling and destroys eye tissues. These diseases can slightly reduce vision or lead to severe vision loss.

The term "uveitis" is used because the diseases often affect a part of the eye called the uvea. Nevertheless, uveitis is not limited to the uvea. These diseases also affect the lens, retina, optic nerve, and vitreous, producing reduced vision or blindness.

Uveitis may be caused by problems or diseases occurring in the eye or it can be part of an inflammatory disease affecting other parts of the body.

It can happen at all ages and primarily affects people between 20-60 years old.

Uveitis can last for a short (acute) or a long (chronic) time. The severest forms of uveitis reoccur many times... Read more about Uveitis NIH - National Eye Institute

What works? Research summarized

Evidence reviews

Steroid implants for chronic uveitis not caused by infection

Uveitis describes a group of eye diseases caused by inflammation (redness and swelling, etc.). Uveitis is the fifth most common cause of vision loss in high‐income countries, accounting for 5% (1 in 20 cases) to 20% (1 in 5 cases) of blindness, with the disease affecting mostly working‐age people. In low‐income countries, uveitis accounts for 2.4% (1 in 40 cases) to 24% (1 in 4 cases) of legal blindness. These figures are for all types of uveitis (infectious and non‐infectious uveitis), so the prevalence of non‐infectious uveitis (the focus of this review) is likely lower than these estimates.

Comparison of artificial lenses placed in eyes with uveitis during cataract surgery

Cataract, a cloudy lens within the eye, is a major complication in people with uveitis (inflammation of the middle layer of the eye). Different types of artificial lenses (intraocular lenses, IOLs) are available to insert into the eye after removal of the cloudy natural lens during cataract surgery. The purpose of this review is to summarize the effects of different artificial lenses in adults with uveitis.

Vitrektomie bei Uveitis im Kindes- und Jugendalter [Update on vitrectomy for pediatric uveitis]

PURPOSE: The role of vitrectomy in pediatric uveitis has as yet not been established. Addressing this question has been reinforced since the recent introduction of the new and relatively well tolerated medical treatment options using biologicals, i. e. TNFalpha blocking agents.

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Summaries for consumers

Steroid implants for chronic uveitis not caused by infection

Uveitis describes a group of eye diseases caused by inflammation (redness and swelling, etc.). Uveitis is the fifth most common cause of vision loss in high‐income countries, accounting for 5% (1 in 20 cases) to 20% (1 in 5 cases) of blindness, with the disease affecting mostly working‐age people. In low‐income countries, uveitis accounts for 2.4% (1 in 40 cases) to 24% (1 in 4 cases) of legal blindness. These figures are for all types of uveitis (infectious and non‐infectious uveitis), so the prevalence of non‐infectious uveitis (the focus of this review) is likely lower than these estimates.

Comparison of artificial lenses placed in eyes with uveitis during cataract surgery

Cataract, a cloudy lens within the eye, is a major complication in people with uveitis (inflammation of the middle layer of the eye). Different types of artificial lenses (intraocular lenses, IOLs) are available to insert into the eye after removal of the cloudy natural lens during cataract surgery. The purpose of this review is to summarize the effects of different artificial lenses in adults with uveitis.

Rifabutin for treating pulmonary tuberculosis

Among current challenges in tuberculosis treatment are reducing the length of time that drugs must be taken to less than six months and finding ways to safely combine tuberculosis drugs with those used in the treatment of HIV infection. Rifabutin is a drug that has the potential to address these issues if substituted for rifampicin, a mainstay of current treatment. This review identified five trials involving 924 people, but none were of high quality. The review found no significant differences between rifabutin‐ and rifampicin‐containing treatment in curing tuberculosis and preventing relapse, but higher doses of rifabutin might be associated with more adverse effects and there was no evidence that it could shorten treatment. However, very few people with HIV and tuberculosis, who are most likely to benefit from use of rifabutin due to its lack of interaction with antiretroviral drugs, were included in the trials. Better quality clinical trials are needed to understand the place of rifabutin in the treatment of people with tuberculosis, particularly those who also have HIV.

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More about Uveitis

Photo of a young adult

Also called: Intraocular inflammation

Other terms to know:
Uvea

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