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Tuberous Sclerosis

A genetic disorder in which benign (not cancer) tumors form in the kidneys, brain, eyes, heart, lungs, and skin. This disease can cause seizures, mental disabilities, and different types of skin lesions.

PubMed Health Glossary
(Source: NIH - National Cancer Institute)

What works? Research summarized

Evidence reviews

Drugs that aim to relieve clinical symptoms of tuberous sclerosis complex

We reviewed the evidence about the effect of rapamycin or rapalogs for reducing the severity of clinical symptoms in people with tuberous sclerosis complex.

Efficacy and safety of sirolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: a systematic review

PURPOSE: We evaluate the efficacy and safety of sirolimus in the treatment of renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.

Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis

The authors concluded that melatonin decreased sleep latency and the number of wakes per night and increased total sleep time in people with intellectual disabilities. These conclusions appeared supported by the evidence, but the limited search and incomplete reporting of review methods made it difficult to assess their reliability.

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Summaries for consumers

Drugs that aim to relieve clinical symptoms of tuberous sclerosis complex

We reviewed the evidence about the effect of rapamycin or rapalogs for reducing the severity of clinical symptoms in people with tuberous sclerosis complex.

Treatment of infantile spasms

The optimum treatment for infantile spasms has yet to be proven with confidence, in part because of the different aims of existing studies. However, some useful conclusions can be drawn from current evidence.

Childhood Astrocytomas Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of childhood astrocytomas.

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More about Tuberous Sclerosis

Photo of a child

Also called: Adenoma sebaceum syndrome, Tuberose sclerosis, Tuberous sclerosis complex, Tuberous sclerosis syndrome, TS, TSC

Other terms to know:
Genetic, Lesion, Seizures

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