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The presence of elevated levels of uric acid in the blood.

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(Source: NIH - National Institute of Arthritis and Musculoskeletal and Skin Diseases)

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Evidence reviews

Irbesartan for hypertensive patients with hyperuricaemia: a systematic review

Bibliographic details: Wu FB, Zhan M, Tang Y.  Irbesartan for hypertensive patients with hyperuricaemia: a systematic review. Chinese Journal of Evidence-Based Medicine 2011; 11(11): 1290-1294

Chronic Kidney Disease (Partial Update): Early Identification and Management of Chronic Kidney Disease in Adults in Primary and Secondary Care

The Renal National Service Framework (NSF), and the subsequent NICE Clinical Practice Guideline for early identification and management of adults with chronic kidney disease (CKD) in primary and secondary care (CG73), served to emphasise the change in focus in renal medicine from treatment of established kidney disease to earlier identification and prevention of kidney disease.

Effects of urate-lowering therapy in hyperuricemia on slowing the progression of renal function: a meta-analysis

Uric acid (UA) is generally regarded as an independent risk factor for poor prognosis of patients with kidney disease. However, urate-lowering therapy (ULT) in asymptomatic hyperuricemia is conservative. Whether the beneficial effect on renal function can be achieved by lowering UA remains uncertain. A compound search for randomized controlled trials was conducted in databases consisting of MEDLINE, EMBASE, the Cochrane Library, the Chinese Biomedical Literature Database, and Chinese Science and Technology periodical databases. Two investigators independently screened these studies, assessed the included trials, and extracted data. Eleven articles with a total number of 753 participants met the criteria and were included in our meta-analysis. The results showed that ULT was associated with a decrease in serum creatinine and an increase in eGFR. Our study further confirms that ULT may have beneficial effects on slowing the progression of renal function.

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Summaries for consumers

Drug therapy to treat high levels of uric acid in individuals with high blood pressure

Uric acid is the natural end product produced by the breakdown of the body's tissues and a person's food, most notably protein. Uric acid is usually removed from the blood by the kidneys and eliminated from the body in the urine. However, if too much uric acid is produced or the kidneys are not able to remove it from the blood as usual, uric acid levels in the blood increase (termed hyperuricemia). A link between hyperuricemia and high blood pressure (a major health matter worldwide) has been recognized since the 19th century. Today, there is more evidence that this is an important association. The aim of this review was to evaluate whether lowering levels of uric acid in the blood could also lower blood pressure. Such an approach could represent a new goal and/or a therapeutic option for individuals with hypertension.

Febuxostat for treating chronic gout

This summary of a Cochrane review represents what we know from research about the effect of febuxostat for treating chronic gout.

Pegloticase for chronic gout

‐        it is unknown whether pegloticase can improve the pain and function of people with chronic gout.

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More about Hyperuricemia

Photo of an adult

Also called: Hyperuricaemia, Uricacidaemia, Uricacidemia

See Also: Gout

Other terms to know:
Uric Acid

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