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Plaque Psoriasis

A chronic disease of the skin marked by red patches covered with white scales.

PubMed Health Glossary
(Source: NIH - National Cancer Institute)

About Psoriasis

Psoriasis is a chronic (long-lasting) skin disease of scaling and inflammation that affects greater than 3 percent of the U.S. population, or more than 5 million adults. Although the disease occurs in all age groups, it primarily affects adults. It appears about equally in males and females.

Psoriasis occurs when skin cells quickly rise from their origin below the surface of the skin and pile up on the surface before they have a chance to mature. Usually this movement (also called turnover) takes about a month, but in psoriasis it may occur in only a few days... NIH - National Institute of Arthritis and Musculoskeletal and Skin Diseases

What works? Research summarized

Evidence reviews

New Immunomodulating Drugs in Treating Moderate to Severe Psoriasis [Internet]

Favorable effects on skin lesions and quality of life in patients with moderate to severe plaque psoriasis have been shown after treatment with infliximab, etanercept and efalizumab for 3 to 6 months (strong scientific evidence). The scientific evidence is insufficient to assess the long-term effects of the 3 drugs, as well as the potential, uncommon and long-term side effects.

Skin treatments for chronic plaque psoriasis

Chronic plaque psoriasis is the most common type of psoriasis. Although any part of the body may be affected, the most commonly affected sites are the elbows, knees, and scalp. 'Topical' treatments (i.e. treatments applied to the skin) are usually tried first. These include vitamin D products, topical corticosteroids, tar‐based preparations, dithranol, salicylic acid, and vitamin A products. As chronic plaque psoriasis is a long‐term condition, it is important to find out which treatments work best and what adverse effects they have. This review describes average benefits of different treatments, while recognising that individuals will vary in their experience of each treatment.

Treatments for guttate psoriasis

Psoriasis is a skin disease that causes scaly pink patches. Guttate psoriasis is a particular form of the disease that usually affects children and young adults. It can happen on its own, or as a complication of ordinary (chronic plaque) psoriasis. Often, it follows a bacterial throat infection or tonsillitis. Antibiotics and tonsillectomy as treatments for guttate psoriasis are covered by another review. This review could find no evidence, from trials, about the effects of any other commonly used treatments for guttate psoriasis.

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Summaries for consumers

Ixekizumab (Taltz) for psoriasis: Ixekizumab (Taltz) for adults with plaque psoriasis who are able to have systemic treatment

In 2017, the Institute for Quality and Efficiency in Health Care (IQWiG, Germany) assessed the advantages and disadvantages of ixekizumab (trade name: Taltz) for people with moderate to severe plaque psoriasis who are able to have systemic treatment. For the purpose of this comparison, the manufacturer provided data from 83 patients. Of these, 40 people had treatment with ixekizumab, while 43 had the standard treatment with fumaric acid esters.

Ixekizumab (Taltz) for psoriasis: Ixekizumab (Taltz) for adults with plaque psoriasis who are unable to have different systemic treatment

In 2017, the Institute for Quality and Efficiency in Health Care (IQWiG, Germany) assessed the advantages and disadvantages of ixekizumab (trade name: Taltz) for people with moderate to severe plaque psoriasis in whom a different systemic treatment didn't work well enough or wasn't possible. For the purpose of this comparison, the manufacturer provided data from 302 patients. Of these, 136 people had treatment with ixekizumab, while 166 had treatment with ustekinumab.

Skin treatments for chronic plaque psoriasis

Chronic plaque psoriasis is the most common type of psoriasis. Although any part of the body may be affected, the most commonly affected sites are the elbows, knees, and scalp. 'Topical' treatments (i.e. treatments applied to the skin) are usually tried first. These include vitamin D products, topical corticosteroids, tar‐based preparations, dithranol, salicylic acid, and vitamin A products. As chronic plaque psoriasis is a long‐term condition, it is important to find out which treatments work best and what adverse effects they have. This review describes average benefits of different treatments, while recognising that individuals will vary in their experience of each treatment.

See all (16)

More about Plaque Psoriasis

Photo of an adult

Also called: Psoriatic

Other terms to know:
PUVA Therapy, Photodynamic Therapy (PDT), UVB Radiation

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