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What works? Research summarized

Evidence reviews

Currently there is no clear evidence that cholesterol drugs reduce melanoma risk.

Some studies have suggested that medicines (such as statins and fibrates) taken to lower blood cholesterol may reduce the risk of melanoma skin cancer. Our review of 16 studies did not find any clear evidence to support such a suggestion, but we cannot exclude a useful effect of such drugs until more studies become available.

The use of Statins, cholesterol lowering agents, in patients with multiple sclerosis (MS)

MS is an inflammatory demyelinating disease of the human central nervous system and it is thought to be related to abnormal working of the immune system. Preliminary studies have shown that statins, cholesterol lowering agents, have potential immunological regulation effects which may be beneficial for MS. Furthermore, statins are usually orally administered, are less expensive than other MS treatment, and are easily available.

Dietary advice by dietitians to lower blood cholesterol can be more effective than advice by doctors, but may not be more effective than self‐help resources.

Blood cholesterol level is an important indicator of the risk of heart disease. This review looked at the effectiveness of dietary advice given by dietitians to lower blood cholesterol, compared with the effectiveness of dietary advice given by other types of health professional or using self‐help resources. The review found that advice by dietitians to lower blood cholesterol was more effective than that of doctors (in the short to medium term), but possibly not more effective than using self‐help resources. There was no evidence to suggest that dietary advice given by dietitians was more effective than that given by nurses.

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Summaries for consumers

High cholesterol: Lowering cholesterol without tablets

High cholesterol levels could mean an increased risk of cardiovascular disease. People who would like to lower their risk don't necessarily have to take medication. General measures like changing your diet can also have a beneficial effect and improve your heart health. The treatment of high cholesterol focuses more on reducing the risk of cardiovascular disease over the long term rather than on lowering cholesterol levels. Many people who want to do something about their high cholesterol levels would rather not take medication. Various general measures are recommended for the prevention of cardiovascular disease, although they don't necessarily lower cholesterol. They include the following: Not smokingReducing the amount of saturated fats in your dietGetting a lot of exerciseLosing weight

Currently there is no clear evidence that cholesterol drugs reduce melanoma risk.

Some studies have suggested that medicines (such as statins and fibrates) taken to lower blood cholesterol may reduce the risk of melanoma skin cancer. Our review of 16 studies did not find any clear evidence to support such a suggestion, but we cannot exclude a useful effect of such drugs until more studies become available.

The use of Statins, cholesterol lowering agents, in patients with multiple sclerosis (MS)

MS is an inflammatory demyelinating disease of the human central nervous system and it is thought to be related to abnormal working of the immune system. Preliminary studies have shown that statins, cholesterol lowering agents, have potential immunological regulation effects which may be beneficial for MS. Furthermore, statins are usually orally administered, are less expensive than other MS treatment, and are easily available.

See all (170)

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