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Nicotine (Into the mouth)

Helps you quit smoking.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Nicotine oral chewing gum and lozenges are used to help you stop smoking. Nicotine is absorbed from the gum or lozenge in the mouth and enters the blood stream. This replaces the nicotine you would get from smoking and makes the withdrawal effects from not smoking less severe. The amount of nicotine is decreased over time until use is stopped. This medicine is available without a prescription, but… Read more
Brand names include
Commit, Equate Mini Nicotine Lozenge - Fast Dissolving - Mint, Exact Nicotine Lozenge - Mint, Good Neighbor Pharmacy Nicotine, Good Neighbor Pharmacy Nicotine Gum, Good Neighbor Pharmacy Nicotine Polacrilex, Good Sense Nicotine Polacrilex, Good Sense Nicotine Polacrilex Lozenge - Mint, Health Mart Nicotine Polacrilex, Leader Nicotine Polacrilex, Leader Nicotine Polacrilex Gum, Nic-Assist - Mint, Nicorelief, Nicorette, Nicotine Mini Lozenge, Premier Value nicotine polacrilex, Quit Nicotine Gum - Mint, Sunmark Nicotine, Sunmark Nicotine Lozenge, Thrive
Other forms
Absorbed through the skin, By breathing, Into the nose
Drug classes About this
Smoking Cessation Agent

What works? Research summarized

Evidence reviews

Cost-Effectiveness of Varenicline, Bupropion and Nicotine Replacement Therapy for Smoking Cessation [Internet]

Background Smoking is an important risk factor for several diseases, including different cancers, lung diseases and cardiovascular diseases. About 21% of the Norwegian population are daily smokers.

No evidence of the efficacy of nicotine for Alzheimer's disease

Nicotine has been related to recovery of memory in humans and animal models and some observational studies have been compatible with a protective effect of nicotine inhalation against Alzheimer's disease. At present, there is great controversy over this possible effect of tobacco use, and evidence is inconclusive. This review found no evidence on which to recommend nicotine for Alzheimer's disease.

Nicotine for schizophrenia

People with schizophrenia tend to smoke heavily and to a greater extent when compared to other patient groups. In this review we aimed to investigate this by searching for good quality evidence from randomised controlled trials on the effect of nicotine for schizophrenia, and/or to ascertain whether nicotine modifies the side effects of antipsychotics. Unfortunately we found no trials that met our inclusion criteria to support or refute this. There is a need for good quality randomised controlled trials that investigate the effects of nicotine for schizophrenia.

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Summaries for consumers

No evidence of the efficacy of nicotine for Alzheimer's disease

Nicotine has been related to recovery of memory in humans and animal models and some observational studies have been compatible with a protective effect of nicotine inhalation against Alzheimer's disease. At present, there is great controversy over this possible effect of tobacco use, and evidence is inconclusive. This review found no evidence on which to recommend nicotine for Alzheimer's disease.

Nicotine for schizophrenia

People with schizophrenia tend to smoke heavily and to a greater extent when compared to other patient groups. In this review we aimed to investigate this by searching for good quality evidence from randomised controlled trials on the effect of nicotine for schizophrenia, and/or to ascertain whether nicotine modifies the side effects of antipsychotics. Unfortunately we found no trials that met our inclusion criteria to support or refute this. There is a need for good quality randomised controlled trials that investigate the effects of nicotine for schizophrenia.

Transdermal nicotine for the treatment of active ulcerative colitis

Ulcerative colitis is largely a disease of nonsmokers and patients who have quit smoking. Randomised controlled trials were therefore developed to test the hypothesis that nicotine patches can induce remission of a flare of ulcerative colitis. This review provides evidence that transdermal nicotine is superior to placebo (fake patch) for the treatment of active ulcerative colitis. However, patients treated with transdermal nicotine were significantly more likely to experience side effects than patients receiving placebo or standard medical therapy. Its use is therefore limited in some patients. The review did not identify any significant advantage for transdermal nicotine therapy compared to standard medical therapy.

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