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Lorcaserin (By mouth)

Used in combination with diet and exercise to help you reach and maintain a healthy weight.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Lorcaserin is used together with a reduced-calorie diet and proper exercise to help you lose weight. It is also used in overweight people who may also have diabetes, high blood pressure, high cholesterol, or heart disease. This medicine is available only with your doctor's prescription… Read more
Brand names include
Belviq, Belviq XR
Drug classes About this
Antiobesity Agent

What works? Research summarized

Evidence reviews

Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs

This review concluded that lorcaserin resulted in modest weight loss and appeared to be well tolerated. The authors' conclusions reflect the evidence presented, but it is unclear whether the small changes in weight, BMI and other outcomes measured as a result of treatment with lorcaserin represent clinically significant benefits.

Obesity Interventions Delivered in Primary Care for Patients with Diabetes: A Review of Clinical Effectiveness [Internet]

A Statistics Canada report indicates that reported cases of diabetes among Canadians aged 12 years or older increased from 5.8% in 2007 to 6.5% in 2012; and in 2012, 14.7% of obese Canadians 18 years or older had diabetes compared with 5.1% of those who were not obese. In view of the potential health and wellness benefit of weight loss to obese diabetic patients, this report aims to provide current evidence on the clinical effectiveness of various obesity management interventions that could be used in primary care settings to halt or slow the progression of type 2 diabetes.

Long‐term effects of weight‐reducing drugs in people with elevated blood pressure

Doctors often recommend that people who are overweight or obese with elevated blood pressure lose weight, which may include taking anti‐obesity drugs to assist in weight and blood pressure reduction. Two active ingredients (rimonabant and sibutramine) were withdrawn from the market in 2009 and 2010, respectively. Current guidelines for the pharmacological management of obesity quote five medications (orlistat, lorcaserin, phentermine/topiramate, naltrexone/bupropion, and liraglutide) that have been approved for long‐term weight reduction by the US Food and Drug Administration. However, two of these drugs (phentermine/topiramate and lorcaserin) did not obtain approval in Europe.

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Summaries for consumers

Long‐term effects of weight‐reducing drugs in people with elevated blood pressure

Doctors often recommend that people who are overweight or obese with elevated blood pressure lose weight, which may include taking anti‐obesity drugs to assist in weight and blood pressure reduction. Two active ingredients (rimonabant and sibutramine) were withdrawn from the market in 2009 and 2010, respectively. Current guidelines for the pharmacological management of obesity quote five medications (orlistat, lorcaserin, phentermine/topiramate, naltrexone/bupropion, and liraglutide) that have been approved for long‐term weight reduction by the US Food and Drug Administration. However, two of these drugs (phentermine/topiramate and lorcaserin) did not obtain approval in Europe.

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