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Zolmitriptan (By mouth)

Treats migraine headaches. This medicine does not prevent migraine headaches. This medicine is a triptan.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Zolmitriptan is used to treat acute migraine headaches in adults. It is not used to prevent migraine headaches and is not used for cluster headaches. Zolmitriptan works in the brain to relieve the pain from migraine headaches. It belongs to the group of medicines called triptans. Many people find that their headaches go away completely after they take zolmitriptan. Other people find that their… Read more
Brand names include
Zomig, Zomig-ZMT
Other forms
Into the nose
Drug classes About this
Antimigraine

What works? Research summarized

Evidence reviews

Zolmitriptan for acute migraine attacks in adults

Migraine is a complex condition with a wide variety of symptoms. It affects about 1 person in 8, mainly women aged 30 to 50 years. For many people, the main feature is a painful, and often disabling, headache. Other symptoms include feeling sick, vomiting, disturbed vision, and sensitivity to light, sound, and smells.

Meta-analysis of the efficacy and safety of zolmitriptan in the acute treatment of migraine

The authors concluded that zolmitriptan 2.5mg tablet was effective for acute migraine with similar efficacy to almotriptan 12.5mg, eletriptan 40mg and sumatriptan 50mg and greater efficacy than naratriptan 2.5mg for pain-free response at two hours. Findings that were based predominantly on single studies and incomplete reporting of review methods made it difficult to assess the reliability of the conclusions.

Triptans for acute cluster headache

Cluster headaches are excruciating headaches of extreme intensity. They can last for several hours, are usually on one side of the head only, and affect men more than women. Multiple headaches can occur over several days. Fast pain relief is important because of the intense nature of the pain with cluster headache.

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Summaries for consumers

Zolmitriptan for acute migraine attacks in adults

Migraine is a complex condition with a wide variety of symptoms. It affects about 1 person in 8, mainly women aged 30 to 50 years. For many people, the main feature is a painful, and often disabling, headache. Other symptoms include feeling sick, vomiting, disturbed vision, and sensitivity to light, sound, and smells.

Comparing Triptans

How do triptans compare in treating migraines?

Medication for migraines

Migraine attacks can be treated with painkillers or migraine medication. If needed, medicine for nausea and vomiting can be taken as well. But if painkillers are taken too often they themselves may cause headaches.Lying down in a dark, cool room may be enough to relieve mild migraines. Migraines are usually very painful, though, so most people take medication to get through them. Over-the-counter painkillers may be effective enough for moderate pain. Stronger medication is sometimes needed for severe migraines.  If you often have migraines, it is a good idea to have different kinds of medicine on hand.The following medications can be used to treat migraine:The group of painkillers known as NSAIDs (non-steroidal anti-inflammatory drugs) and acetaminophen (paracetamol)Anti-nausea medication Special migraine medication (triptans and ergotamines)

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