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Trastuzumab (By injection)

Treats cancer, including breast, stomach, and esophageal cancer.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Trastuzumab injection is used to treat HER2-overexpressing new or metastatic (cancer that has spread) breast cancer. It can be used alone or with other cancer medicines (eg, carboplatin, cyclophosphamide, docetaxel, doxorubicin, paclitaxel). Trastuzumab injection is also used in combination with cisplatin and capecitabine or 5-fluorouracil to treat HER2-overexpressing metastatic (cancer that has… Read more
Brand names include
Herceptin, Ogivri
Drug classes About this
Antineoplastic Agent, Immunological Agent

What works? Research summarized

Evidence reviews

Trastuzumab Emtansine -- Benefit Assessment According to §35a Social Code Book V [Internet]

The aim of the present report is to assess the added benefit of trastuzumab emtansine in patients with human epidermal growth factor receptor 2 (HER2)-positive, unresectable, locally advanced or metastatic breast cancer who previously received trastuzumab and a taxane, separately or in combination. Patients should have either received prior treatment for locally advanced or metastatic disease, or developed disease recurrence during or within 6 months of completing adjuvant therapy.

Efficacy and safety of trastuzumab in early breast cancer

Patients with early breast cancer may have HER2‐positive or ‐negative tumours. HER2‐positive cancers tend to be more aggressive. Knowing whether a cancer has high levels of the HER2 protein (about one in five breast cancers) influences the choice of treatment. Trastuzumab (brand name Herceptin) is a drug specifically available for these patients. The aim of the cancer treatment is to eliminate micrometastases at an early stage (i.e. adjuvant) so that more women survive without recurrence of the disease.

Efficacy and safety of trastuzumab in metastatic breast cancer

Tumours characterised by the presence of the HER2 protein are found in about one in five women with metastatic breast cancer. These tend to be more aggressive and the prognosis and choice of treatment are affected. Trastuzumab (Herceptin®) is a targeted biological drug (a monoclonal antibody) that attaches to the HER2 protein, blocking the growth of malignant cells.

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Summaries for consumers

Efficacy and safety of trastuzumab in early breast cancer

Patients with early breast cancer may have HER2‐positive or ‐negative tumours. HER2‐positive cancers tend to be more aggressive. Knowing whether a cancer has high levels of the HER2 protein (about one in five breast cancers) influences the choice of treatment. Trastuzumab (brand name Herceptin) is a drug specifically available for these patients. The aim of the cancer treatment is to eliminate micrometastases at an early stage (i.e. adjuvant) so that more women survive without recurrence of the disease.

Efficacy and safety of trastuzumab in metastatic breast cancer

Tumours characterised by the presence of the HER2 protein are found in about one in five women with metastatic breast cancer. These tend to be more aggressive and the prognosis and choice of treatment are affected. Trastuzumab (Herceptin®) is a targeted biological drug (a monoclonal antibody) that attaches to the HER2 protein, blocking the growth of malignant cells.

Metastatic breast cancer: Treatments and possible consequences

When breast cancer is diagnosed, the aim of treatment is usually to remove all of the tumor. But this is no longer possible if it has spread to other parts of the body. Then the aim of treatment is to keep your overall health and quality of life as good as possible for as long as possible. The goal of treatment for metastatic breast cancer is to stop or slow down the growth of the tumor. It is also possible to reduce the symptoms and possible side effects of treatment and to treat associated medical conditions. Cancer-related pain can be treated with well-managed pain relief therapy. If treatment is carefully planned and tailored to a person's specific situation, and if their overall health is good, it is often possible to keep the disease under control for years, even if they have metastatic tumors, and have a good quality of life despite the symptoms.

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