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Tizanidine (By mouth)

Treats muscle spasticity.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Tizanidine is used to help relax certain muscles in your body. It relieves spasms, cramping, and tightness of the muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine. Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition. Tizanidine acts on the central nervous Read more
Brand names include
Comfort Pac w/Tizanidine, Zanaflex, Zanaflex Capsule
Drug classes About this
Skeletal Muscle Relaxant, Centrally Acting

What works? Research summarized

Evidence reviews

Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications

This guideline covers the management of spasticity and co-existing motor disorders and their early musculoskeletal complications in children and young people (from birth up to their 19th birthday) with non-progressive brain disorders.

Not enough evidence about the effects of drugs used to try and reduce spasticity in the limbs after spinal cord injury

A major problem after spinal cord injury is muscle resistance to having the arms or legs moved (spasticity). There can also be spasms. This can severely limit a person's mobility and independence, and can cause pain, muscle problems, and sleep difficulties. Treatments to try and reduce spasticity include exercise, and drugs to try and decrease the muscle tone. The review found there was not enough evidence from trials to assess the effects of the range of drugs used to try and relieve spasticity after spinal cord injury. The authors of the review call for more research and make recommendations as to how this research should be conducted.

Drugs (with the exception of botulinum toxin) to treat spasticity after stroke

We wanted to learn whether there was evidence for using drugs for spasticity in people with stroke, and if so, to identify whether drugs that acted on the whole body (systemic drugs) differed in their effects to drugs that acted in a localised area of the body (local drugs).

See all (25)

Summaries for consumers

Comparing Muscle Relaxants

How do muscle relaxants compare in treating spasticity caused by a neurological disorder?

Not enough evidence about the effects of drugs used to try and reduce spasticity in the limbs after spinal cord injury

A major problem after spinal cord injury is muscle resistance to having the arms or legs moved (spasticity). There can also be spasms. This can severely limit a person's mobility and independence, and can cause pain, muscle problems, and sleep difficulties. Treatments to try and reduce spasticity include exercise, and drugs to try and decrease the muscle tone. The review found there was not enough evidence from trials to assess the effects of the range of drugs used to try and relieve spasticity after spinal cord injury. The authors of the review call for more research and make recommendations as to how this research should be conducted.

Drugs (with the exception of botulinum toxin) to treat spasticity after stroke

We wanted to learn whether there was evidence for using drugs for spasticity in people with stroke, and if so, to identify whether drugs that acted on the whole body (systemic drugs) differed in their effects to drugs that acted in a localised area of the body (local drugs).

See all (7)

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