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Sumatriptan/Naproxen (By mouth)

Treats migraines. This medicine contains an NSAID.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Sumatriptan and naproxen combination is used to treat acute migraine attacks. It is not used to prevent migraine headaches or to treat cluster headaches. This medicine often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound. Sumatriptan is a serotonin receptor agonist that works in the brain to relieve… Read more
Brand names include
Treximet
Drug classes About this
Antimigraine

What works? Research summarized

Evidence reviews

Drug Class Review: Triptans: Final Report Update 4 [Internet]

Triptans, also called serotonin 5-hydroxytryptamine (5-HT)(1B/1D) agonists, are used to treat migraine and certain other headaches. Triptans act by binding to serotonin receptors in the brain, which leads to a reversal of blood vessel swelling. Triptans may be taken subcutaneously, orally as tablets, capsules, or quick-dissolving wafers, or intranasally as a spray. Currently, 7 triptans are available in the United States (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan), as well as a fixed-dose combination product containing sumatriptan plus naproxen. Comparing the clinical efficacy and harms of the different triptans has been an area of considerable interest to researchers and patients, but is complex because of the large variety of outcome measures that can be measured in studies. The purpose of this review is to compare the efficacy, effectiveness, and harms of triptans.

Drugs for the acute treatment of migraine in children and adolescents

Migraine is a painful and debilitating disorder that is common in children (under 12 years of age) and adolescents (12 to 17 years of age). Common symptoms reported during a migraine attack are headache, nausea, vomiting, and sensitivity to light and sound. Many treatments for migraine are available, of which the most common are paracetamol (also known as acetaminophen), ibuprofen and other anti‐inflammatories, and triptans. Not all triptan medications are approved for use in children or adolescents, and approvals vary from country to country.

Acute migraine therapy: recent evidence from randomized comparative trials

The review found that triptan/NSAID combination therapy was more effective than one agent. All triptans were similarly effective, but almotriptan was better tolerated than sumatriptan. Limitations of the review methodology, including a limited validity assessment, meant that the reliability of the results could not be assessed.

Summaries for consumers

Comparing Triptans

How do triptans compare in treating migraines?

Drugs for the acute treatment of migraine in children and adolescents

Migraine is a painful and debilitating disorder that is common in children (under 12 years of age) and adolescents (12 to 17 years of age). Common symptoms reported during a migraine attack are headache, nausea, vomiting, and sensitivity to light and sound. Many treatments for migraine are available, of which the most common are paracetamol (also known as acetaminophen), ibuprofen and other anti‐inflammatories, and triptans. Not all triptan medications are approved for use in children or adolescents, and approvals vary from country to country.

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