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Rotigotine (Absorbed through the skin)

Treats symptoms of Parkinson disease, such as jerky muscle movements, muscle stiffness, and slow movement. Also treats restless legs syndrome (RLS).

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Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Rotigotine transdermal patch is used to treat symptoms of Parkinson's disease, sometimes called shaking palsy. It is a dopamine agonist that helps improve muscle control and reduce muscle stiffness to allow more normal movements of the body. Rotigotine is also used to treat a condition called Restless Legs Syndrome (RLS). RLS is a neurologic disorder that affects sensation and movement in the… Read more
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What works? Research summarized

Evidence reviews

Rotigotine (Neupro) (Transdermal Patch) [Internet]

The objective of this report was to perform a systematic review of the beneficial and harmful effects of rotigotine for the treatment of the signs and symptoms of idiopathic Parkinson disease (PD).

Rotigotine transdermal patch in Parkinson's disease: a systematic review and meta-analysis

BACKGROUND AND METHODS: The efficacy and safety of rotigotine transdermal patch in Parkinson's disease (PD) were studied in some clinical trials. We performed a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy, tolerability, and safety of rotigotine transdermal patch versus placebo in PD.

A mixed treatment comparison of gabapentin enacarbil, pramipexole, ropinirole and rotigotine in moderate-to-severe restless legs syndrome

OBJECTIVE: A mixed treatment comparison (MTC) was performed to investigate the relative efficacy and safety of licensed pharmaceuticals for moderate-to-severe restless legs syndrome (RLS).

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Summaries for consumers

Options for Treating Restless Legs Syndrome: A Review of the Research for Adults

This summary will cover: What RLS is Treatment options for RLS What researchers have found about RLS treatments

Dopamine agonists for restless legs syndrome

We could include 38 trials in the meta‐analyses which investigated the efficacy and safety of dopamine agonist treatment compared to placebo or to other treatments for RLS. The studies were performed mostly in European and Northern American countries. Treatment durations varied from one week to seven months, but most treatments had durations of one to 12 weeks. Patients suffered from moderate to severe RLS and were treated with the dopamine agonists cabergoline, lisuride, pergolide, pramipexole, ropinirole, rotigotine, and sumanirole.

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