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Micromedex DrugNotes [Internet]. Ann Arbor (MI): Truven Health Analytics, an IBM company; 1974-2018.

Micromedex DrugNotes [Internet].

Pseudoephedrine/Triprolidine (By mouth)

Pseudoephedrine (soo-doe-e-FED-rin), Triprolidine (trye-PROE-li-deen)

Published: April 1, 2018.

Treats runny nose, nasal congestion, sneezing, and itchy or watery eyes caused by hay fever or the common cold. This medicine is a combination of an antihistamine and a decongestant.

Brand Name(s)

Aprodine, Ed A-Hist PSE, Nasal Decongestant Antihistamine, Silafed

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to pseudoephedrine or triprolidine. You should not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects.

How to Use This Medicine

Liquid, Tablet

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Follow the instructions on the medicine label if you are using this medicine without a prescription.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate or freeze the liquid form of this medicine.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • Tell your doctor if you have diabetes, thyroid problems, high blood pressure, glaucoma, an enlarged prostate, or a history of heart disease.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Do not give this medicine to a child under 6 years of age unless your doctor tells you to.
  • If your symptoms do not improve within 7 days or if they get worse, call your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

If you notice these less serious side effects, talk with your doctor:

  • Trouble sleeping.
  • Feelings of restlessness or excitement (especially in children).

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

© 2018 Truven Health Analytics LLC Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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