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Pseudoephedrine (By mouth)

Treats stuffy nose and sinuses.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Pseudoephedrine is used to relieve nasal or sinus congestion caused by the common cold, sinusitis, and hay fever and other respiratory allergies. It is also used to relieve ear congestion caused by ear inflammation or infection. Some of these preparations are available only with your doctor's prescription. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 Read more
Brand names include
12 Hour Cold Maximum Strength, 12 Hour Decongestant, 12-Hour Cold Relief, Biofed, Cenafed, Children's Sudafed, Chlor-Trimeton Nasal Decongestant, Congestion, Contac 12-Hour, Dimetapp Decongestant, Efidac 24 Pseudoephedrine, ElixSure Congestion Children's, Genaphed, Good Neighbor Pharmacy Nasal Decongestant, Good Neighbor Pharmacy Suphedrin, Good Neighbor Suphedrine Children's, Good Sense 12 Hour Decongestant, Good Sense Nasal Decongestant, Kodet Se, Nasal Decongestant, Nexafed, Pediacare Decongestant Infants, Quality Choice Suphedrine, Simply Stuffy, Sudafed
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Combinations including this drug

What works? Research summarized

Evidence reviews

Effect of oral pseudoephedrine on blood pressure and heart rate: a meta-analysis

This review of adults aged 20 to 63 years concluded that oral pseudoephedrine modestly increased systolic blood-pressure and heart rate, particularly with immediate-release formulations, higher doses of medication and short-term medication administration. The authors' conclusions are reasonable, but the effect of pseudoephedrine may have been overestimated given the inclusion criteria used for the review.

A systematic review of methamphetamine precursor regulations

AIMS: To assess the effectiveness of methamphetamine precursor regulations in reducing illicit methamphetamine supply and use.

Do nasal decongestants used alone relieve cold symptoms?

We wanted to find out if nasal decongestants used alone can ease nasal congestion symptoms in people with colds.

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Summaries for consumers

Do nasal decongestants used alone relieve cold symptoms?

We wanted to find out if nasal decongestants used alone can ease nasal congestion symptoms in people with colds.

Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus

Obesity is closely related to type 2 diabetes and weight reduction is an important part of the care delivered to obese persons with diabetes. This review of drugs for weight loss among adults with type 2 diabetes revealed weight loss of between 2.0 and 5.1 kg for fluoxetine, orlistat and sibutramine at follow‐up of up to 57 weeks. The long‐term effects remain uncertain. Adverse events were common in all three drugs: gastrointestinal side effects with orlistat; tremor, somnolence, and sweating with fluoxetine; and palpitations with sibutramine. There were few studies examining other drugs used for weight loss in populations with diabetes.

Acetaminophen (also called paracetamol) for the common cold in adults

The common cold is the most frequent viral infection of the upper respiratory tract. Adults in the US experience two to four colds per year. The symptoms of the common cold usually include nasal obstruction, headache, sore throat, sneezing, cough, malaise and nasal discharge. There is no effective therapy for the common cold and most medications are symptomatic. Acetaminophen (also called paracetamol) is widely used as the major ingredient in combination medications for the common cold. However, there is little information about the effectiveness and safety of this treatment. We reviewed studies to evaluate the effectiveness and safety of acetaminophen in the treatment of the common cold in adults. The evidence is current to February 2013.

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