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Promethazine (By injection)

Treats allergies and motion sickness. Also used before and after surgery and other procedures as a sedative and to control pain or nausea and vomiting. This medicine is a phenothiazine.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Promethazine injection is used to relieve or prevent some types of allergy or allergic reactions. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult. Promethazine is also used to… Read more
Brand names include
Antinaus 50, Phenergan, Promacot, Prorex
Other forms
By mouth, Into the rectum
Drug classes About this
Antiemetic, Antivertigo, Gastrointestinal Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Haloperidol plus promethazine for psychosis‐induced aggression

Emergency psychiatric services are often required to help calm people who are aggressive because they are experiencing distressing psychoses. In such situations quick‐acting medication is usually given. Haloperidol is an antipsychotic typically used to treat schizophrenia, and promethazine is a strong tranquilliser that can help to reduce nervous tension.

[Haloperidol plus promethazine for agitated patients - a systematic review]

OBJECTIVE: Rapid and safe tranquillisation is sometimes unavoidable. We conducted this systematic review to determine the value of the combination haloperidol plus promethazine, frequently used in Brazil.

Magnesium sulphate versus lytic cocktail for eclampsia

Magnesium sulphate performs better than lytic cocktail in preventing maternal deaths, further fits, respiratory depression, coma and pneumonia for pregnant women with eclampsia.

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Summaries for consumers

Haloperidol plus promethazine for psychosis‐induced aggression

Emergency psychiatric services are often required to help calm people who are aggressive because they are experiencing distressing psychoses. In such situations quick‐acting medication is usually given. Haloperidol is an antipsychotic typically used to treat schizophrenia, and promethazine is a strong tranquilliser that can help to reduce nervous tension.

Magnesium sulphate versus lytic cocktail for eclampsia

Magnesium sulphate performs better than lytic cocktail in preventing maternal deaths, further fits, respiratory depression, coma and pneumonia for pregnant women with eclampsia.

Medicines in the treatment of emergency department nausea and vomiting

We reviewed the effects of medicines in the treatment of nausea and vomiting in adults in the emergency department.

See all (11)

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