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Pregabalin (By mouth)

Treats nerve and muscle pain, including fibromyalgia. Also treats seizures.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Pregabalin is used with other medicines to help control partial seizures (convulsions) in the treatment of epilepsy. This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. Pregabalin is also used for postherpetic neuralgia (pain that occurs after shingles) and pain caused by nerve damage from diabetes or a spinal cord injury. It is used… Read more
Brand names include
Lyrica
Drug classes About this
Anticonvulsant, Neuropathic Pain Agent

What works? Research summarized

Evidence reviews

The use of pregabalin analgesia for patients with chronic prostatitis/chronic pelvic pain syndrome

It has been suggested that chronic prostatitis/chronic pelvic pain syndrome is due to pain caused by the nerves in or around the prostate. Pregabalin is a pain killer that is specific for nerve pain. Therefore we conducted a search of the literature to evaluate the use of pregabalin for this ailment and whether or not it was better than placebo.

Pregabalin for acute and chronic pain in adults

Pregabalin relieves pain caused by damage to nerves, either from injury or disease. Antiepileptics (such as pregabalin) are medicines used for treating epilepsy, but are also effective for treating pain. The type of pain that responds well to pregabalin treatment is neuropathic pain (pain caused by damage to nerves). This includes postherpetic neuralgia (persistent pain in an area previously affected by shingles) and painful complications of diabetes, as well as fibromyalgia. Only a minority of patients with these types of pain will have a substantial benefit, and somewhat more will have moderate benefit. With pregabalin daily doses of 300 mg to 600 mg, the patient global impression of change rating of much or very much improved was about 35% in postherpetic neuralgia, 50% in painful diabetic neuropathy, and 40% in fibromyalgia. There is no evidence that pregabalin is effective in acute conditions where pain is already established, and in chronic conditions in which nerve damage is not the prime source of the pain, such as arthritis.

Pregabalin add‐on for drug‐resistant partial epilepsy

Use of pregabalin in combination with other antiepileptic drugs can reduce the frequency of seizures, but has some adverse effects. The overall evidence for reducing seizures was rated as moderate in quality.

See all (119)

Summaries for consumers

The use of pregabalin analgesia for patients with chronic prostatitis/chronic pelvic pain syndrome

It has been suggested that chronic prostatitis/chronic pelvic pain syndrome is due to pain caused by the nerves in or around the prostate. Pregabalin is a pain killer that is specific for nerve pain. Therefore we conducted a search of the literature to evaluate the use of pregabalin for this ailment and whether or not it was better than placebo.

Pregabalin for acute and chronic pain in adults

Pregabalin relieves pain caused by damage to nerves, either from injury or disease. Antiepileptics (such as pregabalin) are medicines used for treating epilepsy, but are also effective for treating pain. The type of pain that responds well to pregabalin treatment is neuropathic pain (pain caused by damage to nerves). This includes postherpetic neuralgia (persistent pain in an area previously affected by shingles) and painful complications of diabetes, as well as fibromyalgia. Only a minority of patients with these types of pain will have a substantial benefit, and somewhat more will have moderate benefit. With pregabalin daily doses of 300 mg to 600 mg, the patient global impression of change rating of much or very much improved was about 35% in postherpetic neuralgia, 50% in painful diabetic neuropathy, and 40% in fibromyalgia. There is no evidence that pregabalin is effective in acute conditions where pain is already established, and in chronic conditions in which nerve damage is not the prime source of the pain, such as arthritis.

Pregabalin add‐on for drug‐resistant partial epilepsy

Use of pregabalin in combination with other antiepileptic drugs can reduce the frequency of seizures, but has some adverse effects. The overall evidence for reducing seizures was rated as moderate in quality.

See all (31)

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