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Pravastatin (By mouth)

Treats high cholesterol and triglyceride levels. May reduce the risk of heart attack, stroke, and related health conditions. This medicine is a statin.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Pravastatin is used together with a proper diet to lower cholesterol and triglycerides (fat) in the blood. This medicine may help prevent or slow down medical problems, like atherosclerosis (hardening of the arteries), that are caused by fats clogging the blood vessels. It may also be used to prevent certain types of heart and blood vessel problems in patients with risk factors for heart… Read more
Brand names include
Pravachol
Drug classes About this
Antihyperlipidemic

What works? Research summarized

Evidence reviews

Statins for the prevention of dementia

Dementia (including Alzheimer's disease) is a global healthcare concern; the number of people affected worldwide is predicted to double every 20 years, reaching 74.7 million in 2010 and 131.5 million in 2050. Therefore, it is important to find means of preventing dementia. It has been suggested that high levels of cholesterol in the serum (part of the blood) may increase the risk of dementia and that treatment with cholesterol‐lowering medicines such as statins may reduce the risk of dementia.

Does pravastatin promote cancer in elderly patients: a meta-analysis

This review evaluated the effect of pravastatin therapy on cancer risk, according to age. The authors concluded that pravastatin may be associated with an increased risk of cancer among elderly people, but further verification was needed. The conclusions should be regarded with some caution because of limitations in the review process.

Are statins created equal: evidence from randomized trials of pravastatin, simvastatin, and atorvastatin for cardiovascular disease prevention

This review assessed the relative efficacy of pravastatin, simvastatin and atorvastatin. The authors concluded that the evidence suggests there is no statistically significant difference in long-term cardiovascular outcomes between standard doses of these statins. Statements on relative efficacy were based on indirect comparisons, thus the authors' cautious conclusion appears appropriate.

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Summaries for consumers

Statins for the prevention of dementia

Dementia (including Alzheimer's disease) is a global healthcare concern; the number of people affected worldwide is predicted to double every 20 years, reaching 74.7 million in 2010 and 131.5 million in 2050. Therefore, it is important to find means of preventing dementia. It has been suggested that high levels of cholesterol in the serum (part of the blood) may increase the risk of dementia and that treatment with cholesterol‐lowering medicines such as statins may reduce the risk of dementia.

Comparing Statins and Combination Drugs

How do statins and combination drugs compare in lowering "bad" cholesterol (LDL-c)?

The effect of the timing of statin administration on hyperlipidaemia

Cardiovascular disease (CVD), which comprises heart attacks (myocardial infarction), angina, and strokes, is the principal cause of death in the world and is a major cause of morbidity worldwide. High blood cholesterol is linked to CVD events and is an important risk factor. Therefore, decreasing high blood cholesterol is an important way to reduce the chances of suffering a CVD event. Blood cholesterol may come from foods that are high in fat, and is also produced by some of our body’s organs (most of this production is at night (between 12:00 am and 6:00 am).

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