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Perphenazine (By mouth)

Treats schizophrenia. May also be used to treat nausea and vomiting.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Drug classes About this
Antiemetic, Antipsychotic
Combinations including this drug

What works? Research summarized

Evidence reviews

Depot perphenazine decanoate and enanthate for schizophrenia

Long acting depot preparations (decanoate and enanthate) of the oral antipsychotics perphenazine are available for people with schizophrenia. Evidence available for their efficacy and safety is limited. This review identifies randomised trials comparing depot perphenazine to other depot antipsychotics and perphenazine decanoate to enanthate.

Perphenazine for schizophrenia

People with schizophrenia often hear voices or see things (hallucinations) and have strange beliefs (delusions). The main treatment for these symptoms of schizophrenia is antipsychotic drugs. Perphenazine is an old antipsychotic drug (typical or first‐generation) formulated in the 1950s with an effectiveness similar to another antipsychotic drug called haloperidol. Perphenazine is particularly popular in Northern European countries and Japan.

Perphenazine versus low‐potency first‐generation drugs for schizophrenia

Schizophrenia is a severe mental illness where people experience ‘positive symptoms’ (such as hearing voices, seeing things and having strange beliefs) and ‘negative symptoms’ (such as tiredness, apathy and loss of emotion).

See all (58)

Summaries for consumers

Depot perphenazine decanoate and enanthate for schizophrenia

Long acting depot preparations (decanoate and enanthate) of the oral antipsychotics perphenazine are available for people with schizophrenia. Evidence available for their efficacy and safety is limited. This review identifies randomised trials comparing depot perphenazine to other depot antipsychotics and perphenazine decanoate to enanthate.

Perphenazine for schizophrenia

People with schizophrenia often hear voices or see things (hallucinations) and have strange beliefs (delusions). The main treatment for these symptoms of schizophrenia is antipsychotic drugs. Perphenazine is an old antipsychotic drug (typical or first‐generation) formulated in the 1950s with an effectiveness similar to another antipsychotic drug called haloperidol. Perphenazine is particularly popular in Northern European countries and Japan.

Perphenazine versus low‐potency first‐generation drugs for schizophrenia

Schizophrenia is a severe mental illness where people experience ‘positive symptoms’ (such as hearing voices, seeing things and having strange beliefs) and ‘negative symptoms’ (such as tiredness, apathy and loss of emotion).

See all (11)

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