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Oxycodone, Rapid Release (By mouth)

Treats moderate to severe pain. This medicine is a narcotic pain reliever.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Brand names include
Oxaydo, Oxy IR, Roxicodone
Other forms
By mouth, Oral route
Drug classes About this
Combinations including this drug

What works? Research summarized

Evidence reviews

Tamper-Resistant Oxycodone: A Review of the Clinical Evidence and Cost-effectiveness [Internet]

Requiring tamper-resistant properties for products that contain particular controlled substances in order to be sold can be part of efforts to address prescription drug abuse. The purpose of this review is to evaluate the effectiveness of tamper-resistant formulations in curbing abuse and misuse of oxycodone.

Buprenorphine/Naloxone Versus Methadone for the Treatment of Opioid Dependence: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness and Guidelines [Internet]

In 2013, Suboxone (buprenorphine/naloxone) became available as a generic and its direct cost, and cost differential with methadone, decreased. Buprenorphine/naloxone has several advantages compared with methadone. Methadone is a full agonist; there is no ceiling to respiratory depression or sedation effects and an overdose can be fatal. Buprenorphine also has a long half-life but because it is a partial agonist, it has a ceiling effect (effect plateaus at higher doses) and thus the risk of overdose is decreased. Other advantages of buprenorphine/naloxone include its long duration of action which allows for every second day dosing if needed; its administration as a sublingual tablet; its lack of requirements of an exemption to be prescribed; and its formulation with less potential for abuse.

The Management of Hip Fracture in Adults [Internet]

Although hip fracture is predominantly a phenomenon of later life, it may occur at any age in people with osteoporosis or osteopenia, and this guidance is applicable to adults across the age spectrum. Skills in its management have, however been accrued, researched and reported especially by collaborative teams specialising in the care of older people (using the general designation ‘orthogeriatrics’). These skills are applicable in hip fracture irrespective of age, and the guidance includes recommendations that cover the needs of younger patients by drawing on such skills in an organised manner.

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