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Omeprazole (By mouth)

Treats heartburn, a damaged esophagus, stomach ulcers, and gastroesophageal reflux disease (GERD). This medicine is a proton pump inhibitor (PPI).

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Omeprazole is used to treat certain conditions where there is too much acid in the stomach. It is used to treat gastric and duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). GERD is a condition where the acid in the stomach washes back up into the esophagus. Sometimes omeprazole is used in combination with antibiotics (eg, amoxicillin, clarithromycin) to treat… Read more
Brand names include
First - Omeprazole, First-Omeprazole, Good Neighbor Pharmacy Omeprazole, Good Sense Omeprazole, Leader Omeprazole, Omeclamox-Pak, PrevidolRx Analgesic Pak, Quality Choice Omeprazole Magnesium, Rite Aid Omeprazole, Sunmark Omeprazole, TopCare Omeprazole
Drug classes About this
Gastric Acid Secretion Inhibitor
Combinations including this drug

What works? Research summarized

Evidence reviews

Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses

Bibliographic details: Datto C, Hellmund R, Siddiqui MK.  Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. Open Access Rheumatology: Research and Reviews 2013; 5

[Meta analysis of efficacy of omeprazole versus famotidine in treatment of duodenal ulcer]

Bibliographic details: Chen Y, Qu L, Li X, Feng W.  [Meta analysis of efficacy of omeprazole versus famotidine in treatment of duodenal ulcer]. Pharmaceutical Care and Research 2012; 12(1): 67-69 Available from: http://dx.doi.org/10.5428/pcar20120119

Effectiveness and safety of China-made omeprazole in treating acute non-variceal upper gastrintestinal bleeding: a meta-analysis

Bibliographic details: Liu WP, Huang CY.  Effectiveness and safety of China-made omeprazole in treating acute non-variceal upper gastrintestinal bleeding: a meta-analysis. Chinese Journal of Evidence-Based Medicine 2013; 13(6): 723-727 Available from: http://www.cjebm.org.cn/oa/DArticle.aspx?type=view&id=20130621

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Summaries for consumers

Comparing Proton Pump Inhibitors

How do proton pump inhibitors compare in gastroesophageal reflux disease (GERD)?

Gastritis: How can you prevent peptic ulcers caused by painkillers?

When taken for a long time, painkillers like diclofenac and ibuprofen can lead to ulcers in the stomach and bowel. But the risk of this happening can be clearly reduced by also taking medication to protect your stomach.

Drugs for reducing stomach acid for people with cystic fibrosis

We reviewed the evidence for using drugs to reduce stomach acid in people with cystic fibrosis.

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