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Mirtazapine (By mouth)

Treats depression.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Mirtazapine is used to treat depression. Mirtazapine belongs to a group of medicines called tetracyclic antidepressants. These medicines work in the central nervous system (CNS) to make certain chemicals in the brain stronger. This medicine is available only with your doctor's prescription… Read more
Brand names include
Remeron, Remeron RD, Remeron Soltab
Drug classes About this
Antidepressant

What works? Research summarized

Evidence reviews

Health Economic Evaluation of Venlafaxine, Duloxetine, Bupropion, and Mirtazapine Compared to Further Prescribable Pharmaceutical Treatments [Internet]

On the basis of the results of a benefit assessment of the test drugs venlafaxine, duloxetine, bupropion, and mirtazapine, the aim of the present investigation is to conduct a health economic evaluation of these test drugs in order to derive a recommendation for a reimbursement price. The relevant comparators of the therapeutic area (tricyclic antidepressants [TCAs] plus maprotiline, selective serotonin reuptake inhibitors [SSRIs], agomelatine, and trazodone) were included in the health economic evaluation. The study population consisted of previously untreated adult patients with depression.

Mirtazapine versus other antidepressive agents for depression

Major depression is characterised by a persistent low mood and loss of interest and pleasure. These symptoms are often accompanied by loss of appetite, insomnia, fatigue, poor concentration, inappropriate guilty feelings and even suicide. Depression was the third leading cause of disease burden among all diseases experienced by humankind in 2002. Antidepressants are used in treatment for major depression. They are the mainstay of treatment. Among them, mirtazapine is known to have a unique pharmacological profile and thus is supposed to differ in its efficacy and adverse effects profile in comparison with other antidepressants.

Bupropion, mirtazapine, and reboxetine in the treatment of depression: Executive summary of final report A05-20C, Version 1.1

The aim of this research is to assess the benefit of treatment with bupropion, mirtazapine or reboxetine in treating the acute phase of depression, in maintenance therapy (relapse prevention), and in recurrence prevention compared to treatment with placebo each other treatment with other antidepressants in each case in adult patients with depression. The focus of the investigation was on patient-relevant outcomes.

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Summaries for consumers

Mirtazapine versus other antidepressive agents for depression

Major depression is characterised by a persistent low mood and loss of interest and pleasure. These symptoms are often accompanied by loss of appetite, insomnia, fatigue, poor concentration, inappropriate guilty feelings and even suicide. Depression was the third leading cause of disease burden among all diseases experienced by humankind in 2002. Antidepressants are used in treatment for major depression. They are the mainstay of treatment. Among them, mirtazapine is known to have a unique pharmacological profile and thus is supposed to differ in its efficacy and adverse effects profile in comparison with other antidepressants.

Mirtazapine as an add‐on treatment for schizophrenia

Schizophrenia is a severe mental illness. Those affected typically exhibit abnormal social behaviour and an inability to judge what is real. There are three main types of symptoms. Positive symptoms are where patients hear voices or see things that are not there and can also have fixed false beliefs (delusions). Examples of negative symptoms are lack of motivation and withdrawal from social activities. Cognitive symptoms include a reduced ability to concentrate or difficulty in using information to make decisions. Schizophrena can be extremely debilitating, greatly affecting a person's social functioning and their ability to live independently.

Treatment for amphetamine withdrawal

Symptoms of amphetamine withdrawal during the initial days of abstinence from chronic amphetamine use can prompt individuals to return to regular drug use. No medications demonstrate significant effects over placebo in reducing symptoms of acute amphetamine withdrawal.

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