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Metoprolol (By injection)

Reduces risk of serious problems caused by a heart attack. This medicine is a beta-blocker.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Metoprolol injection is used to reduce the risk of death from an acute heart attack. It is given to people who have already had a heart attack. This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood… Read more
Brand names include
Lopressor
Other forms
By mouth
Drug classes About this
Antianginal, Antiarrhythmic, Group II, Antihypertensive, Antimigraine, Cardiovascular Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Rheumatic heart disease with metoprolol: a systematic review

Bibliographic details: Yang L, Yu AH, Tian JH, Yang KH, Xue HY, Yao GY, Shao WB.  Rheumatic heart disease with metoprolol: a systematic review. Chinese Pharmacological Bulletin 2010; 26(12): 1603-1607

Health technology assessment of different doses of metoprolol for atrial fibrillation

Bibliographic details: Wang H, Dong B R, Yang M.  Health technology assessment of different doses of metoprolol for atrial fibrillation. Chinese Journal of Evidence-Based Medicine 2008; 8(5): 334-339

Efficacy and safety of different doses of metoprolol in the treatment of primary hypertension: a systematic review

Bibliographic details: Xia Z Q, Dong B R.  Efficacy and safety of different doses of metoprolol in the treatment of primary hypertension: a systematic review. Chinese Journal of Evidence-Based Medicine 2007; 7(11): 802-809

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Summaries for consumers

Beta‐blockers for cardiac risk reduction in people undergoing non‐cardiac vascular surgery

As the population is ageing, more people will undergo major vascular surgery, which carries an increased risk of cardiac complications. The increased risk of cardiac complications is often the result of asymptomatic heart disease. Treating severe symptoms, such as critical limb ischaemia (severely narrowed arteries of the lower limbs resulting in rest pain, ulcers, or gangrene), in people with peripheral arterial disease is a common reason for undergoing vascular surgery, which carries an increased risk heart attack (myocardial infarction) ranging from 5% to 24% during and shortly after surgery. There is clear evidence for the use of beta‐blockers (a class of medications used to treat certain heart conditions as well as high‐blood pressure and other conditions) to reduce cardiac risk in people with known heart disease, and it has been suggested that beta‐blockers may reduce short‐term cardiac illness (morbidity) and death (mortality) in people undergoing major non‐cardiac vascular surgery.

Beta blockers for peripheral arterial disease

Intermittent claudication, the most common symptom of atherosclerotic peripheral arterial disease, results from decreased blood flow to the legs during exercise. Beta blockers, a large group of drugs, have been shown to decrease death among people with high blood pressure and coronary artery disease and are used to treat various disorders. They reduce heart activity but can also inhibit relaxation of smooth muscle in blood vessels, bronchi and the gastrointestinal and genitourinary tracts. The non‐selective beta blockers propranolol, timolol and pindolol are effective at all beta‐adrenergic sites in the body, whereas other beta blockers, such as atenolol and metoprolol, are selective for the heart.

Beta‐blockers for children with congestive heart failure

The term congestive heart failure describes a disorder in which the heart is unable to sufficiently and efficiently pump blood through the body. Depending on the severity of the condition, this causes breathlessness and fatigue due to insufficient oxygen supply, and an accumulation of fluids in tissues and organs.

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