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Metoprolol (By mouth)

Treats high blood pressure, angina (chest pain), and heart failure. May lower the risk of death after a heart attack. This medicine is a beta-blocker.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Metoprolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. A lower blood… Read more
Brand names include
Lopressor, Toprol XL
Other forms
By injection
Drug classes About this
Antianginal, Antiarrhythmic, Group II, Antihypertensive, Antimigraine, Cardiovascular Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Rheumatic heart disease with metoprolol: a systematic review

Bibliographic details: Yang L, Yu AH, Tian JH, Yang KH, Xue HY, Yao GY, Shao WB.  Rheumatic heart disease with metoprolol: a systematic review. Chinese Pharmacological Bulletin 2010; 26(12): 1603-1607

Health technology assessment of different doses of metoprolol for atrial fibrillation

Bibliographic details: Wang H, Dong B R, Yang M.  Health technology assessment of different doses of metoprolol for atrial fibrillation. Chinese Journal of Evidence-Based Medicine 2008; 8(5): 334-339

Carvedilol versus metoprolol for primary hypertension: a systematic review

Bibliographic details: Niu XW, Xu H, He SL, Chen D, Yan D, He ZY, Yao YL.  Carvedilol versus metoprolol for primary hypertension: a systematic review. Chinese Journal of Evidence-Based Medicine 2013; 13(8): 963-970

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Summaries for consumers

Beta blockers for peripheral arterial disease

Intermittent claudication, the most common symptom of atherosclerotic peripheral arterial disease, results from decreased blood flow to the legs during exercise. Beta blockers, a large group of drugs, have been shown to decrease death among people with high blood pressure and coronary artery disease and are used to treat various disorders. They reduce heart activity but can also inhibit relaxation of smooth muscle in blood vessels, bronchi and the gastrointestinal and genitourinary tracts. The non‐selective beta blockers propranolol, timolol and pindolol are effective at all beta‐adrenergic sites in the body, whereas other beta blockers, such as atenolol and metoprolol, are selective for the heart.

Beta‐blockers for children with congestive heart failure

The term congestive heart failure describes a disorder in which the heart is unable to sufficiently and efficiently pump blood through the body. Depending on the severity of the condition, this causes breathlessness and fatigue due to insufficient oxygen supply, and an accumulation of fluids in tissues and organs.

Medical treatment of vascular risk factors for reducing death and cardiovascular events in people with abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a potentially life‐threatening condition where the aorta enlarges and can ultimately burst, leading to massive internal bleeding. Current guidelines recommend that AAAs of 55 mm or more should be surgically repaired because, at this size, the risk of rupture outweighs the risk of surgical repair. AAAs between 30 mm and 54 mm in size are not as high risk and are generally monitored by regular scans to check for further enlargement. Recent research has shown that even after the aneurysm is repaired, the survival rate in people with AAA is poorer than in people without AAA. In most cases, the cause of death is a cardiovascular event, such as a heart attack or a stroke. Conditions such as high blood pressure or high cholesterol increase the risk of cardiovascular death. However, both conditions can be reversed through medical treatment. Given the increased risk of mortality with AAA, it is important to determine which medical treatment is most effective in preventing cardiovascular death in people with AAA.

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