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Methylene Blue (Into a vein)

Treats methemoglobinemia.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Methylene blue injection is used to treat a condition called methemoglobinemia. This condition occurs when the blood cannot deliver oxygen where it is needed in the body. This medicine is to be given only by or under the supervision of a doctor… Read more
Brand names include
Provayblue
Drug classes About this
Antidote, Diagnostic Agent, Diagnostic Agent, Kidney Function
Combinations including this drug

What works? Research summarized

Evidence reviews

A meta-analysis of randomized controlled trials comparing methylene blue-directed biopsies with random biopsies in the surveillance of Barrett's esophagus

Bibliographic details: Admad NZ, Ahmed A.  A meta-analysis of randomized controlled trials comparing methylene blue-directed biopsies with random biopsies in the surveillance of Barrett's esophagus. Esophagus 2010; 7(4): 207-213

Systematic review of intravenous methylene blue in parathyroid surgery

BACKGROUND: Methylene blue is an intraoperative adjunct for localization of enlarged parathyroid glands. The availability of preoperative and other intraoperative localization methods, and the reported adverse effects of methylene blue make its routine use debatable. The aim of this study was to perform a systematic review of the use of methylene blue in parathyroidectomy.

Methylene blue as a vasopressor: a meta-analysis of randomised trials

The authors concluded that methylene blue increased the arterial blood pressure and systemic vascular resistance, without a detrimental effect on survival, for patients with vasoplegia. These conclusions reflect the evidence presented, but a lack of high-quality trials, very small samples, and wide variation between trials, make the reliability of the findings uncertain.

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Summaries for consumers

Treatments for hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a long‐term, distressing skin condition involving multiple painful boils in skin creases, such as the armpits, groin, and genital region, estimated to affect about 1 in 100 people. It typically begins in early adulthood and has a large impact on quality of life because of pain, scarring, and low self‐esteem. Doctors and the general public have largely ignored the condition, in part because people with HS do not wish to draw attention to their condition, so there is a relative lack of evidence to guide treatment.

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