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Meropenem (By injection)

Treats infections.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Meropenem injection is used to treat infections caused by bacteria. It works by killing the bacteria or preventing their growth. This medicine will not work for colds, flu, or other virus infections. This medicine is to be given only by or under the direct supervision of your doctor… Read more
Brand names include
Meropenem Novaplus, Merrem IV
Drug classes About this
Antibiotic

What works? Research summarized

Evidence reviews

A meta-analysis of the efficacy and safety of meropenem and imipenem in the treatment of moderate or severe pulmonary infections

Bibliographic details: Xiao H, Cao B, He H, Yin C.  A meta-analysis of the efficacy and safety of meropenem and imipenem in the treatment of moderate or severe pulmonary infections. Chinese Journal of Infection and Chemotherapy 2010; 10(4): 264-269

Systematic review comparing meropenem with imipenem plus cilastatin in the treatment of severe infections

This review compared the effectiveness of meropenem with imipenem plus cilastatin in the treatment of severe infections. The authors concluded that meropenem is significantly more effective in terms of clinical response and bacteriologic response, and is associated with significantly fewer adverse events. This was a relatively well-conducted systematic review and the authors' conclusions are likely to be reliable.

Carbapenems for Multi-Drug Resistant Infections: A Review of Guidelines [Internet]

Carbapenems are beta-lactam antibiotics with a very broad spectrum of activity and act by disrupting the synthesis of bacterial cell walls. Others in the family of beta-lactam antibiotics are cephalosporins, which include cefepime and ceftazidime. In contrast, beta-lactamase inhibitors have little antibacterial activity alone. They include tazobactam and clavulanate. When used with beta-lactams however, the combination therapy provides enhanced and extended spectrum of activity against bacteria containing plasmid-mediated and chromosomal beta-lactamases. In the literature, the terminology “combination therapy” varies. For instance, the combination product piperacillin-tazobactam is often referred to as monotherapy unless combined with other agents such as amikacin or tobramycin.

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Summaries for consumers

Single‐agent antibiotic treatment for cancer patients with fever and low white blood cell counts

Cancer patients develop neutropenia, a decrease in the neutrophil subset of the white blood cells, as a result of chemotherapy. Neutropenia exposes patients to infections, mainly bacterial. Without antibiotic treatment these infections may be fatal, therefore antibiotic treatment is administered when a patient with neutropenia develops fever. The objective of this review was to compare antibiotic treatments currently recommended in consensus guidelines for the initial treatment of cancer patients with fever and neutropenia.

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