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Lubiprostone (By mouth)

Treats constipation. Also treats irritable bowel syndrome (IBS) with constipation in women. This medicine is a stool softener.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Lubiprostone is used to treat long-lasting constipation in adults. It is also used to treat constipation caused by opioids (narcotic pain medicines) in adults with long-lasting pain that is not caused by cancer, or in patients with long-lasting pain caused by a previous cancer or its treatment who do not need weekly increases in opioid dosage. This medicine works by increasing the fluid secretionRead more
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What works? Research summarized

Evidence reviews

Drug Class Review: Constipation Drugs: Final Report [Internet]

Chronic constipation is a disorder characterized by unsatisfactory defecation that results from infrequent stools, difficult stool passage, or both over a time period of at least 12 weeks. In this report, we review the general and comparative effectiveness, safety, and tolerability of drugs for chronic constipation. Our review covers the use of the following in adults and children with chronic constipation and Irritable Bowel Syndrome, constipation-predominant (IBS-C): docusate calcium, docusate sodium, lactulose, lubiprostone, polyethylene glycol 3350, psyllium, and tegaserod.

Treatments for Constipation: A Review of Systematic Reviews [Internet]

Constipation has many definitions and is often described differently depending on the population queried. Physicians may define constipation as a reduction in the frequency of bowel movements to fewer than three times per week while patients identify more with the symptoms associated with constipation such as difficulty passing stool, hard stool consistency, feelings of abdominal cramping, and feelings of incomplete stool passage. Causes of constipation may be primary (idiopathic) or secondary to other factors such as diet, medication, or medical conditions. Constipation can affect anyone as a minor annoyance but up to a quarter of the population experiences it chronically or severely. It can substantially affect quality of life and be debilitating. It is estimated that between 2% to 27% of the population are affected depending upon the definition of constipation used.

Dicyclomine for Gastrointestinal Conditions: A Review of the Clinical Effectiveness, Safety, and Guidelines [Internet]

This Rapid Response report aims to review the clinical effectiveness and safety of dicyclomine for gastrointestinal (GI) conditions. Evidence-based guidelines associated with the use of dicyclomine in the management of GI conditions will also be examined.

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Summaries for consumers

Comparing Drugs for Chronic Constipation

How do the drugs used to treat chronic constipation and irritable bowel syndrome with predominant constipation compare?

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