Home > Drugs A – Z > Lamotrigine (By mouth)

Lamotrigine (By mouth)

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Lamotrigine is used alone or together with other medicines to help control certain types of seizures (e.g., partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. It can also be used in the treatment of bipolar disorder (manic-depressive Read more
Brand names include
LaMICtal ODT Patient Titration Kit Blue, LaMICtal ODT Patient Titration Kit Green, LaMICtal ODT Patient Titration Kit Orange, LaMICtal Starter Kit Blue, LaMICtal Starter Kit Green, LaMICtal Starter Kit Orange, LaMICtal XR Patient Titration Kit Blue, LaMICtal XR Patient Titration Kit Green, LaMICtal XR Patient Titration Kit Orange
Drug classes About this
Anticonvulsant

What works? Research summarized

Evidence reviews

Lamotrigine adjunctive therapy for refractory generalized tonic‐clonic seizures

There is limited evidence that adjunctive lamotrigine reduces seizure frequency in patients with refractory primary generalized tonic‐clonic seizures.

Lamotrigine for schizophrenia

Schizophrenia is a major mental disorder affecting about 1% of the general population. The symptoms of the disorder significantly affect the social, occupational and interpersonal functioning of the affected person. In spite of promising treatments for schizophrenia over the last fifty years, at least one‐fifth to one‐third of affected people fail to respond to treatment. In such cases, additional drugs may be administered to improve treatment response. One such drug is lamotrigine, which was introduced primarily for epilepsy ('fits'). So far there has not been any systematic analysis of those reports that have suggested the benefit of lamotrigine for people with schizophrenia, hence we undertook this review.

Lamotrigine (an antiepileptic drug) for chronic neuropathic pain or fibromyalgia

Neuropathic pain is pain coming from damaged nerves. It is different from pain messages carried along healthy nerves from damaged tissue (a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are not effective in neuropathic pain, while medicines that are sometimes used to treat depression or epilepsy can be very effective in some people with neuropathic pain. Our understanding of fibromyalgia (a condition of persistent, widespread pain and tenderness, sleep problems, and fatigue) is lacking, but fibromyalgia can respond to the same medicines as neuropathic pain.

See all (121)

Summaries for consumers

Lamotrigine adjunctive therapy for refractory generalized tonic‐clonic seizures

There is limited evidence that adjunctive lamotrigine reduces seizure frequency in patients with refractory primary generalized tonic‐clonic seizures.

Lamotrigine for schizophrenia

Schizophrenia is a major mental disorder affecting about 1% of the general population. The symptoms of the disorder significantly affect the social, occupational and interpersonal functioning of the affected person. In spite of promising treatments for schizophrenia over the last fifty years, at least one‐fifth to one‐third of affected people fail to respond to treatment. In such cases, additional drugs may be administered to improve treatment response. One such drug is lamotrigine, which was introduced primarily for epilepsy ('fits'). So far there has not been any systematic analysis of those reports that have suggested the benefit of lamotrigine for people with schizophrenia, hence we undertook this review.

Lamotrigine (an antiepileptic drug) for chronic neuropathic pain or fibromyalgia

Neuropathic pain is pain coming from damaged nerves. It is different from pain messages carried along healthy nerves from damaged tissue (a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines than pain from damaged tissue. Medicines like paracetamol or ibuprofen are not effective in neuropathic pain, while medicines that are sometimes used to treat depression or epilepsy can be very effective in some people with neuropathic pain. Our understanding of fibromyalgia (a condition of persistent, widespread pain and tenderness, sleep problems, and fatigue) is lacking, but fibromyalgia can respond to the same medicines as neuropathic pain.

See all (27)

PubMed Health Blog...

read all...