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Isosorbide Mononitrate (By mouth)

Prevents angina. This medicine is a nitrate.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). It does not work fast enough to relieve the pain of an angina attack that has already started. Isosorbide mononitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its… Read more
Brand names include
Imdur, Imdur ER, Ismo, Monoket
Drug classes About this
Antianginal, Coronary Vasodilator

What works? Research summarized

Evidence reviews

Beta-blockers plus isosorbide-5-mononitrate for prevention of esophageal variceal rebleeding: a systematic review

Bibliographic details: Sun XB, Wang Q, Shi W, Nong CY, Li Y, Chao QC, Zhao C.  Beta-blockers plus isosorbide-5-mononitrate for prevention of esophageal variceal rebleeding: a systematic review. Chinese Journal of Hepatology 2008; 16(8): 632-63318752758

Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices

This review reported that isosorbide mononitrate alone or in combination with beta blockers did not appear to reduce bleeding in primary or secondary prevention of oesophageal varices. Survival may have increased in comparison with endoscopic therapy. Further research was required. These cautious conclusions and recommendations for research appear appropriate given the limitations of the evidence.

Efficacy of beta-adrenergic blocker plus 5-isosorbide mononitrate and endoscopic band ligation for prophylaxis of esophageal variceal rebleeding: a meta-analysis

The authors concluded that beta-adrenergic blocker plus 5-isosorbide mononitrate was as effective as endoscopic band ligation for the prophylaxis of oesophageal variceal re-bleeding. Evidence appeared to support the authors’ conclusions, but limitations in review methods and analyses based on findings of no significant difference from a few trials weaken the strength of this evidence.

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Summaries for consumers

Cervical ripening before first trimester surgical evacuation for non‐viable pregnancy

Using medications or devices to soften and dilate the cervix can reduce the amount of manual dilation required before the uterus is surgically emptied of a non‐viable pregnancy, or miscarriage. The purpose of this cervical ripening is to reduce the possibility of injury to the uterus and cervix and make the procedure easier to perform, although the ripening agents can have side effects.

Nitric oxide donors for cervical ripening and induction of labour

Sometimes it is necessary to bring on labour artificially in the third trimester because of safety concerns for the mother or her baby. Most commonly used cervical ripening or induction agents also cause uterine activity or contraction, which requires close monitoring of mother and baby within a hospital environment.

Tongxinluo (a traditional Chinese medicine) capsules may help patients suffering from unstable angina

Tongxinluo, in capsule form, is a traditional Chinese medicine which consists of herbs and insects. Traditionally it has been thought to have clinical benefits for patients with angina, including the reduction of the occurrence of acute myocardial infarction (AMI), and complications of some types of heart surgery. Some studies also suggest a possible benefit in reducing the frequency and severity of angina attacks and improving symptoms. However, none of these individual studies have been reviewed systematically.

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