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Insulin NPH/Regular (By injection)

Treats diabetes.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Brand names include
Relion Novolin 70/30
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What works? Research summarized

Evidence reviews

Combination Use of Insulin and Incretins in Type 2 Diabetes [Internet]

The objective of this review was to summarize and critically appraise the evidence regarding the clinical effectiveness and harms of combination use of dipeptidyl peptidase-4 (DPP-4) inhibitors or glucagon-like peptide-1 (GLP-1) analogues with insulin. The following research questions were assessed:

Type 1 Diabetes in Adults: Diagnosis and Management

Type 1 diabetes affects over 370,000 adults in the UK, representing approximately 10% of adults diagnosed with diabetes. Given the complexity of its treatment regimens, successful outcomes depend, perhaps more than with any other long-term condition, on full engagement of the adult with type 1 diabetes in life-long day-by-day self-management. In order to support this, the health service needs to provide informed, expert support, education and training as well as a range of other more conventional biomedical services and interventionsfor the prevention and management of long term complications and disability.

Diabetes (Type 1 and Type 2) in Children and Young People: Diagnosis and Management

Diabetes is a long-term condition that can have a major impact on the life of a child or young person, as well as their family or carers. In addition to insulin therapy, diabetes management should include education, support and access to psychological services, as detailed here and in this guideline. Preparations should also be made for the transition from paediatric to adult services, which have a somewhat different model of care and evidence base.

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Summaries for consumers

Type 1 diabetes: Types of insulin

Insulin therapy is essential for everyone who has type 1 diabetes and some people who have type 2 diabetes. Various types of insulin are available. They differ in terms of how quickly and how long they are effective, as well as in their chemical structure. Some types of insulin work quickly (short-acting insulin or rapid-acting insulin), while others only start to work after a certain amount of time, and then work over a longer time period (long-acting or basal insulin). Insulin can be extracted from the pancreas cells of pigs (porcine insulin) or cattle (bovine insulin) and prepared for use in humans. But nowadays most people use genetically engineered insulin for the treatment of diabetes. There are two types of genetically engineered insulin, known as human insulin and insulin analogues. Human insulin is similar to the insulin made in the human body. Insulin analogues have a different chemical structure, but they have a similar effect.

What is the best insulin type and regimen for pregnant women with pre‐existing diabetes?

The insulin needs of pregnant women with type 1 or 2 diabetes change during pregnancy. Insulin is available in many forms, which affect how often and when the insulin is given. These forms vary in the time needed before the insulin has its effect, how long the effect may last, and whether it is made from animals or humans, which may be important personally or culturally. This review looked at the safest and most effective types and ways of giving insulin during pregnancy.

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