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Haloperidol (By injection)

Treats schizophrenia and symptoms of Tourette syndrome.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Haloperidol injection is used to treat nervous, emotional, and mental conditions (e.g., schizophrenia). It is also used to control the symptoms of Tourette's disorder. This medicine should not be used to treat behavior problems in older adult patients who have dementia. This medicine is available only with your doctor's prescription… Read more
Brand names include
Haldol, Haldol Decanoate, Haloperidol Decanoate Novaplus
Other forms
By mouth
Drug classes About this
Antipsychotic

What works? Research summarized

Evidence reviews

No evidence has been found of any significant general improvement in manifestations of agitation, other than aggression, among demented patients treated with haloperidol, compared with controls

Agitation is common in demented patients, and often takes the form of wandering, crying out, and aggression. It is presumed to reflect subjective distress and is associated both with risks to the patient and an increase in caregiver burden. In the present study haloperidol treatment was associated with a lower degree of aggression than was placebo. Adverse effects occurred more frequently in haloperidol treated patients than controls, but similar drop‐out rates among treated and control patients suggested that for some patients adverse effects may have been tolerated because of better control of behaviour. Our findings indicated that there is little evidence to support a benefit of haloperidol on manifestations of agitation other than aggression, and that haloperidol should not be used routinely to treat patients with agitated dementia. Treatment of agitated dementia should be individualized, with careful monitoring of benefits and adverse effects.

Depot haloperidol decanoate for schizophrenia

Synopsis pending.

Haloperidol for the treatment of nausea and vomiting in palliative care patients

Haloperidol is often used to help control nausea (feeling sick) or vomiting (being sick), both of which are common problems for patients with serious life‐threatening illnesses. Haloperidol can be given by mouth or by injection. There has been some research looking at how this drug works in nausea and vomiting caused by surgery and when trying to prevent nausea and vomiting caused by anti‐cancer treatments.

See all (231)

Summaries for consumers

No evidence has been found of any significant general improvement in manifestations of agitation, other than aggression, among demented patients treated with haloperidol, compared with controls

Agitation is common in demented patients, and often takes the form of wandering, crying out, and aggression. It is presumed to reflect subjective distress and is associated both with risks to the patient and an increase in caregiver burden. In the present study haloperidol treatment was associated with a lower degree of aggression than was placebo. Adverse effects occurred more frequently in haloperidol treated patients than controls, but similar drop‐out rates among treated and control patients suggested that for some patients adverse effects may have been tolerated because of better control of behaviour. Our findings indicated that there is little evidence to support a benefit of haloperidol on manifestations of agitation other than aggression, and that haloperidol should not be used routinely to treat patients with agitated dementia. Treatment of agitated dementia should be individualized, with careful monitoring of benefits and adverse effects.

Depot haloperidol decanoate for schizophrenia

Synopsis pending.

Haloperidol for the treatment of nausea and vomiting in palliative care patients

Haloperidol is often used to help control nausea (feeling sick) or vomiting (being sick), both of which are common problems for patients with serious life‐threatening illnesses. Haloperidol can be given by mouth or by injection. There has been some research looking at how this drug works in nausea and vomiting caused by surgery and when trying to prevent nausea and vomiting caused by anti‐cancer treatments.

See all (63)

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