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Glycopyrrolate (By mouth)

Treats peptic ulcers. Also used to treat severe drooling caused by certain conditions (such as cerebral palsy) in children 3 to 16 years of age.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Glycopyrrolate is used to treat peptic ulcers in adults. It is also used to treat chronic, severe drooling caused by certain neurologic disorders (e.g., cerebral palsy) in children 3 to 16 years of age. This medicine is an anticholinergic. Glycopyrrolate may also be used for other conditions as determined by your doctor. This medicine is available only with your doctor's prescription… Read more
Brand names include
Cuvposa, Glycate, Robinul, Robinul Forte
Other forms
By breathing, By injection
Drug classes About this
Cholinergic Antagonist, Gastrointestinal Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Interventions for drooling in children with cerebral palsy

Many children with CP have difficulty controlling saliva. Drooling varies in severity and can be distressing for the children, families and caregivers. Excessive drooling can cause constant damp soiled clothing, unpleasant odour, irritated, chapped or sore skin around the mouth and chin, skin and mouth infections, dehydration, difficulties chewing, interference with speech, damage to books, communication aids, computer and audio equipment. There is also risk of social rejection and social isolation for these children.

Hyoscine vs glycopyrronium for drying respiratory secretions in dying patients

The author of this review concluded that there was no clear evidence to support the choice of hyoscine over glycopyrronium for drying up the secretions that cause the 'death rattle'. A thorough search identified only two relevant studies with conflicting results. The author's interpretation of the evidence was appropriate and the conclusion is likely to be reliable.

Comparative efficacy of aclidinium versus glycopyrronium and tiotropium, as maintenance treatment of moderate to severe COPD patients: a systematic review and network meta-analysis

This review of maintenance treatments for moderate-to-severe chronic obstructive pulmonary disease concluded that aclidinium, tiotropium and glycopyrronium were comparable and better than placebo with respect to improvements in lung function, health-related quality of life and dyspnoea at 12 and 24 week time points. The conclusions are moderately reliable with uncertainty relating to indirect comparison and heterogeneity.

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Summaries for consumers

Interventions for drooling in children with cerebral palsy

Many children with CP have difficulty controlling saliva. Drooling varies in severity and can be distressing for the children, families and caregivers. Excessive drooling can cause constant damp soiled clothing, unpleasant odour, irritated, chapped or sore skin around the mouth and chin, skin and mouth infections, dehydration, difficulties chewing, interference with speech, damage to books, communication aids, computer and audio equipment. There is also risk of social rejection and social isolation for these children.

Management of faecal incontinence and constipation in adults with central nervous system diseases

Individuals with central nervous system disease or injury have a much higher risk of loss of bowel control and severe constipation than other people. This is called neurogenic bowel dysfunction (NBD). It can be very difficult to treat constipation without causing bowel leakage, or to prevent bowel leakage without causing constipation. The time spent on emptying the bowel is nearly always much greater for these individuals. Bowel problems like this cause a lot of anxiety and distress and can reduce the quality of life of those who suffer them. This review of research about NBD could be of interest to individuals with any damage to the central nervous system caused by disease or injury, or present at birth, which has a long term effect on how their bowel works.

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