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Fexofenadine (By mouth)

Treats hay fever symptoms and chronic skin hives and itching.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Fexofenadine is an antihistamine. It is used to relieve the symptoms of hay fever (seasonal allergic rhinitis) and hives of the skin (chronic idiopathic urticaria) . Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Also, in some people histamine can close up the bronchial Read more
Brand names include
Allegra, Allegra Allergy, Allegra ODT, Allergy 24Hr, Children's Allegra Allergy, Children's Allergy Fexofenadine HCl, Good Neighbor Pharmacy Allergy Relief, Health Mart Fexofenadine HCl, Leader Aller-Ease, Rite Aid Allergy Relief, Sunmark Fexofenadine Hydrochloride, TopCare 24-Hour Fexofenadine Hydrochloride, WAL-FEX ALLERGY, Wal-Fex
Drug classes About this
Respiratory Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials

The author's conclusion that the evidence encouraged the use of fexofenadine for the treatment of seasonal allergic rhinitis reflected the evidence presented. This was a generally well conducted review, but the large unexplained discrepancy between the number of participants in the studies and the number included in the analysis means that the conclusion should be viewed with caution.

Drug Class Review: Newer Antihistamines: Final Report Update 2 [Internet]

Antihistamines inhibit the effects of histamine at H1 receptors. They have a number of clinical indications including allergic conditions (e.g., rhinitis, dermatoses, atopic dermatitis, contact dermatitis, allergic conjunctivitis, hypersensitivity reactions to drugs, mild transfusion reactions, and urticaria), chronic idiopathic urticaria (CIU), motion sickness, vertigo, and insomnia.

Dementia: A NICE-SCIE Guideline on Supporting People With Dementia and Their Carers in Health and Social Care

This guideline has been developed to advise on supporting people with dementia and their carers in health and social care. The guideline recommendations have been developed by a multidisciplinary team of health and social care professionals, a person with dementia, carers and guideline methodologists after careful consideration of the best available evidence. It is intended that the guideline will be useful to practitioners and service commissioners in providing and planning high-quality care for those with dementia while also emphasising the importance of the experience of care for people with dementia and carers.

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Summaries for consumers

Comparing New Antihistamines

How do newer antihistamines compare in treating allergic rhinitis?

H1‐antihistamines for chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU) is a condition characterised by a rash of red itchy raised weals or hives, which appear for no identifiable reason. Other names include chronic idiopathic or chronic ordinary urticaria. 'Spontaneous' differentiates this type of urticaria from 'inducible' or 'physical' urticaria, for which there are specific triggers such as cold or pressure. 'Chronic' indicates that the condition has continued for at least six weeks. Hives may be intensely itchy, and the appearance may be unsightly and distressing to sufferers. In some cases, hives can be accompanied by deeper swelling, known as angio‐oedema, which is most common around the eyes and mouth.

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