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Febuxostat (By mouth)

Lowers uric acid levels in the blood in patients with gout.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Febuxostat is used to lower hyperuricemia (high uric acid in the blood) in patients with gout. This medicine is a xanthine oxidase inhibitor. It works by causing less uric acid to be produced by the body. This medicine is available only with your doctor's prescription… Read more
Brand names include
Uloric
Drug classes About this
Antigout

What works? Research summarized

Evidence reviews

Febuxostat for treating chronic gout

This summary of a Cochrane review represents what we know from research about the effect of febuxostat for treating chronic gout.

A systematic review and meta-analysis on the safety and efficacy of febuxostat versus allopurinol in chronic gout

OBJECTIVE: To evaluate the safety and efficacy of febuxostat compared to allopurinol for the treatment of chronic gout.

Efficacy and tolerability of febuxostat in hyperuricemic patients with or without gout: a systematic review and meta-analysis

BACKGROUND: Febuxostat has been approved for the treatment of hyperuricemia in patients with/without gout.

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Summaries for consumers

Febuxostat for treating chronic gout

This summary of a Cochrane review represents what we know from research about the effect of febuxostat for treating chronic gout.

Allopurinol for chronic gout

This summary of a Cochrane review presents what we know from research about the effect of allopurinol compared with placebo or other treatments that reduce uric acid levels in treating people with chronic gout. The review is current to January 2014.

Gout: When is long-term treatment with medication suitable?

Gout can't always be managed by changing your diet or drinking less alcohol. Medication that lowers uric acid levels may then be an option. Long-term treatment with this type of medicine is especially suitable for frequent gout attacks and complications such as kidney stones. Gout is caused by high uric acid levels. If uric acid levels in the blood are too high, uric acid crystals may start to form in the joints and trigger gout attacks. Having high uric acid levels for years can lead to complications and damage the joints. Acute gout can become chronic. But because this doesn't happen to everyone, experts disagree on when to start treatment with medication that lowers uric acid levels. This decision is also a personal one because the medication needs to be taken over a period of several years and it may have side effects or interact with other kinds of medicine. A doctor can help you to carefully consider the pros and cons of the treatment.

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