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Edrophonium (By injection)

Used to diagnose myasthenia gravis and help select the proper treatment. Reverses the effect of certain muscle relaxants during surgery or after an overdose. This medicine is an anticholinesterase agent.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Edrophonium injection is used to help diagnose myasthenia gravis (severe muscle weakness) and may be used to help select the proper treatment for the disease. It is also used to reverse the effects of certain muscle relaxants (eg, gallamine, tubocurarine) during surgery or after an overdose of the muscle relaxant. Edrophonium is an anticholinesterase agent. This medicine is to be given only by or… Read more
Brand names include
Enlon, Reversol
Drug classes About this
Diagnostic Agent, Myasthenia Gravis, Nondepolarizing Muscle Relaxant Antagonist
Combinations including this drug

What works? Research summarized

Evidence reviews

A systematic review of diagnostic studies in myasthenia gravis

This review found that the accuracy of tests for the diagnosis of myasthenia gravis should be interpreted with caution, owing to the methodological limitations of the included studies. Although these conclusions appear appropriately cautious, they should be interpreted with extreme caution given the likelihood that relevant studies have been missed by the limited search conducted.

Dementia: A NICE-SCIE Guideline on Supporting People With Dementia and Their Carers in Health and Social Care

This guideline has been developed to advise on supporting people with dementia and their carers in health and social care. The guideline recommendations have been developed by a multidisciplinary team of health and social care professionals, a person with dementia, carers and guideline methodologists after careful consideration of the best available evidence. It is intended that the guideline will be useful to practitioners and service commissioners in providing and planning high-quality care for those with dementia while also emphasising the importance of the experience of care for people with dementia and carers.

Does this patient have myasthenia gravis?

The review assessed the diagnostic accuracy of signs, symptoms and simple tests for myasthenia gravis. The authors concluded that some symptoms (speech becoming unintelligible after prolonged periods) and signs (peek sign) may be useful to confirm the diagnosis of myasthenia gravis, while the results of some tests (ice test, sleep test, response to anticholinesterase agents) may be useful to rule-in or rule-out the condition. The authors highlighted deficiencies in the methodology of the review and the primary studies, thus the results should be interpreted cautiously.

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