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Dutasteride (By mouth)

Treats benign prostatic hyperplasia (enlarged prostate).

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Note: Women of childbearing potential should not use or handle dutasteride capsules. Dutasteride can cause birth defects in male fetuses. Dutasteride is used alone or in combination with tamsulosin (Flomax®) to treat men who have symptoms of an enlarged prostate gland, which is also known as benign prostatic hyperplasia (BPH). Benign enlargement of the prostate is a problem that can occur in men… Read more
Brand names include
Avodart
Drug classes About this
Benign Prostatic Hypertrophy Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Five‐alpha‐reductase inhibitor drugs, such as finasteride or dutasteride, reduce the risk prostate cancer in men who have routine prostate cancer screening

Five‐alpha‐reductase inhibitor drugs have potential as chemopreventive agents. Reduction of prostate cancer was similar between racial groups, age groups (aged 65 years or older compared to younger age groups) and those with or without a family history of prostate cancer. Reduction of prostate cancer was limited to men who had a baseline prostate specific antigen (PSA) values less than 4.0 ng/mL. However, use of five‐alpha‐reductase inhibitors may also increase the risk of high‐grade prostate cancer in men undergoing prostate cancer screening. Future research is needed to determine if the use of five‐alpha‐reductase inhibitors can reduce prostate cancer in men who are not being regularly screened for prostate cancer. Future studies should also determine whether five‐alpha‐reductase inhibitors can reduce death and prostate cancer death and further evaluate the risk of developing high‐grade prostate cancer.

Dutasteride on benign prostatic hyperplasia: a meta-analysis on randomized clinical trials in 6460 patients

OBJECTIVE: To investigate the clinical effectiveness of dutasteride in the treatment of benign prostatic hyperplasia by meta-analysis.

Systematic review evaluating cardiovascular events of the 5-alpha reductase inhibitor – dutasteride

WHAT IS KNOWN AND OBJECTIVES: A recently published large, long-term randomized controlled trial (RCT) brought into question the safety of dutasteride after a significantly increased risk of 'cardiac failure' was noted in the dutasteride arm of the trial compared with placebo. Our objective was to perform a meta-analysis to assess the risk of cardiovascular adverse events with the use of dutasteride for the prevention or treatment of prostatic disease.

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Summaries for consumers

Five‐alpha‐reductase inhibitor drugs, such as finasteride or dutasteride, reduce the risk prostate cancer in men who have routine prostate cancer screening

Five‐alpha‐reductase inhibitor drugs have potential as chemopreventive agents. Reduction of prostate cancer was similar between racial groups, age groups (aged 65 years or older compared to younger age groups) and those with or without a family history of prostate cancer. Reduction of prostate cancer was limited to men who had a baseline prostate specific antigen (PSA) values less than 4.0 ng/mL. However, use of five‐alpha‐reductase inhibitors may also increase the risk of high‐grade prostate cancer in men undergoing prostate cancer screening. Future research is needed to determine if the use of five‐alpha‐reductase inhibitors can reduce prostate cancer in men who are not being regularly screened for prostate cancer. Future studies should also determine whether five‐alpha‐reductase inhibitors can reduce death and prostate cancer death and further evaluate the risk of developing high‐grade prostate cancer.

Benign enlarged prostate: Which medications can help?

Drugs that help to empty the bladder can relieve symptoms caused by an enlarged prostate. They are often used if the symptoms are such a problem that it is hard to get by in everyday life without treatment. If you have to go to the toilet several times a night and constantly feel the urge to pee during the day too because your bladder no longer fully empties itself, various medications can help. When deciding whether to take a certain medication, it is always a good idea to talk to your doctor about possible interactions with other drugs. Many older men who develop prostate problems are already taking medication for other conditions – such as high blood pressure (hypertension) or chronic illnesses.

Prostate Cancer Prevention (PDQ®): Patient Version

Prostate cancer prevention approaches include avoiding risk factors when possible, increasing protective factors, and chemoprevention. Learn more about prostate cancer prevention in this expert-reviewed summary.

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