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Dronedarone (By mouth)

Treats heart rhythm problems.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Dronedarone is used to lower the chance of going to the hospital for serious heart rhythm problems in patients with a history of paroxysmal or persistent atrial fibrillation. Dronedarone belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep the heart rhythm normal. This medicine is available… Read more
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What works? Research summarized

Evidence reviews

An individual patient-based meta-analysis of the effects of dronedarone in patients with atrial fibrillation

AIMS: Dronedarone is a non-iodinated benzofuran derivative with antiarrhythmic properties. In placebo-controlled atrial fibrillation (AF) trials, the drug was found to have divergent effects on endpoints such as cardiovascular death or hospitalization. The objective of this meta-analysis of all placebo-controlled studies was to provide insights on possible reasons for these divergent effects.

Dronedarone and the incidence of stroke in patients with paroxysmal or persistent atrial fibrillation: a systematic review and meta-analysis of randomized trials

The review found evidence to indicate that dronedarone reduced the risk of stroke or transient ischaemic attack in individuals with paroxysmal or persistent atrial fibrillation, but more research was needed. These conclusions require some caution in interpretation due to lack of significant findings in the random-effects model and a lack of studies in which stroke was a prespecified outcome.

Comparative efficacy of dronedarone and amiodarone for the maintenance of sinus rhythm in patients with atrial fibrillation

This review compared the efficacy and safety of dronedarone versus amiodarone for the prevention of recurrent atrial fibrillation. It concluded that dronedarone was less effective than amiodarone, but had fewer adverse events. Limitations in the conduct and reporting of this review mean that the estimates on which these conclusions were based may not be reliable.

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Summaries for consumers

Antiarrhythmics for maintaining sinus rhythm after reversing atrial fibrillation

Atrial fibrillation is a disease where the heart rhythm is irregular (this is called arrhythmia) and too fast (this is called tachycardia, from the Greek tachy meaning fast). Atrial fibrillation may produce complications, either in the heart (heart failure, syncope) or in other organs (mainly causing embolism, the formation of blood clots in the cavities of the heart that may then travel to other places, for example the brain).

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