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Darunavir (By mouth)

Treats HIV infection. HIV causes AIDS. This medicine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Darunavir is used in combination with ritonavir (Norvir®) and other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). This medicine is given to patients who have already had previous treatment for HIV or who have never taken HIV medicines in the past. Darunavir will not cure or… Read more
Brand names include
Prezista
Drug classes About this
Antiretroviral Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

Darunavir/Cobicistat (Prezcobix) [Internet]

The objective of this systematic review is to examine the beneficial and harmful effects of cobicistat-boosted darunavir (DRV/COBI) 800 mg/150 mg for the treatment of HIV-1 infection in antiretroviral treatment-naive and treatment-experienced patients without darunavir (DRV) resistance-associated mutations (RAMs).

Depression in Adults with a Chronic Physical Health Problem: Treatment and Management

This clinical guideline was commissioned by NICE and developed by the National Collaborating Centre for Mental Health. It sets out clear, evidenceand consensus-based recommendations for healthcare staff on how to treat and manage depression in adults with a chronic physical health problem.

Emtricitabine/Tenofovir for Post-Exposure Prophylaxis Against HIV: A Review of Clinical Effectiveness and Cost-Effectiveness [Internet]

The objective of this Rapid Response report is to evaluate the clinical and cost-effectiveness of TDF plus FTC, with or without integrase strand transfer inhibitors, as compared with other NRTI regimens with or without protease inhibitors boosted with ritonavir.

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Summaries for consumers

Darunavir in a fixed-dose combination (Symtuza) for the treatment of HIV: Overview

The fixed-dose combination of the four drugs darunavir, cobicistat, emtricitabine and tenofovir alafenamide (trade name: Symtuza) has been approved in Germany since September 2017 as a treatment for HIV type 1 in teenagers over the age of 12 (with a body weight of at least 40 kilos) and adults.

Fixed-dose combination with elvitegravir (Genvoya) for the treatment of HIV: Overview

The fixed-dose combination of the four drugs elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide (trade name: Genvoya) has been approved in Germany since November 2015 for the treatment of type 1 HIV (HIV-1) in adults and teenagers over the age of 12.

Drugs assessed by IQWiG: Overview

Since early 2011, the added benefit of most medications containing new active ingredients must be assessed as soon as they enter the market in Germany. The most important results of the IQWiG reviews are summarized here.

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