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Collagenase (On the skin)

Used to clean skin ulcers and severe burns.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Brand names include
Santyl
Other forms
By injection
Drug classes About this
Debriding Agent, Dermatological Agent

What works? Research summarized

Evidence reviews

Collagenase Clostridium histolyticum -- Benefit Assessment According to §35a Social Code Book V [Internet]

The benefit assessment of the active substance collagenase was carried out for the approved therapeutic indication “Dupuytren’s contracture in adult patients with a palpable cord”.

Hydrogel dressings for treating pressure ulcers

Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are areas of injury to the skin or the underlying tissue, or both. Pressure ulcers can be painful, may become infected, and affect quality of life. Those at risk of pressure ulcers include those with spinal cord injuries and people who are immobile or who have limited mobility such as some elderly people and people with acute or chronic conditions. In 2004 the total annual cost of treating pressure ulcers in the UK was estimated as being GBP 1.4 to 2.1 billion, which was equivalent to 4% of the total NHS expenditure. Pressure ulcers have been shown to increase length of hospital stay and the associated hospital costs. Figures from the USA suggest that 'pressure ulcer' was noted as a diagnosis for half a million hospital stays in 2006; for adults, the total hospital costs of these stays was USD 11 billion.

Collagenase for intervertebral disk hernia: a systematic review

Bibliographic details: Meng Y, Wang L, Mao X, Zhou ZK, Li YP.  Collagenase for intervertebral disk hernia: a systematic review. Chinese Journal of Evidence-Based Medicine 2006; 6(12): 885-892

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Summaries for consumers

Hydrogel dressings for treating pressure ulcers

Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are areas of injury to the skin or the underlying tissue, or both. Pressure ulcers can be painful, may become infected, and affect quality of life. Those at risk of pressure ulcers include those with spinal cord injuries and people who are immobile or who have limited mobility such as some elderly people and people with acute or chronic conditions. In 2004 the total annual cost of treating pressure ulcers in the UK was estimated as being GBP 1.4 to 2.1 billion, which was equivalent to 4% of the total NHS expenditure. Pressure ulcers have been shown to increase length of hospital stay and the associated hospital costs. Figures from the USA suggest that 'pressure ulcer' was noted as a diagnosis for half a million hospital stays in 2006; for adults, the total hospital costs of these stays was USD 11 billion.

Which dressings or topical agents are the most effective for healing pressure ulcers?

We reviewed the evidence about the effects of dressings and topical agents (such as ointments, creams and gels) on pressure ulcer healing. There are many different dressings and topical agents available, and we wanted to find out which were the most effective.

Interventions for the management of oral submucous fibrosis

Oral submucous fibrosis is a chronic disease which is commonly found in patients in the Asian subcontinent and the Far East and is characterised by the build up of constricting bands of collagen in the cheeks and adjacent structures of the mouth. The precise cause is unknown but chewing of betel quid as well as other areca nut containing products, excessive use of chillies and spices, poor nutrition and vitamin and iron deficiency have been suggested.

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