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Clozapine (By mouth)

Treats schizophrenia. Also lowers the risk of suicidal behavior in patients who have schizophrenia or schizoaffective disorder.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Clozapine is used to treat severely ill patients with schizophrenia who have used other medicines that did not work well. It is also used to lower risk of suicidal behavior in patients with schizophrenia or schizoaffective disorder. Clozapine changes some of the chemicals in the brain that are thought to cause schizophrenia. This medicine should not be used to treat behavioral problems in older Read more
Brand names include
Clozaril, FazaClo, Versacloz
Drug classes About this
Antipsychotic

What works? Research summarized

Evidence reviews

Newer atypical antipsychotic medication versus clozapine for schizophrenia

Synopsis pending.

Interventions for people with schizophrenia who have too much saliva due to clozapine treatment

Clozapine is an antipsychotic medication used in the treatment of schizophrenia, a mental health problem that can cause symptoms such as hallucinations and delusions and social withdrawal. Clozapine may be useful in those for whom other medications have not worked very well. One of the common side‐effects of clozapine is having too much saliva in the mouth (hypersalivation). This can be embarrassing in public and problematic, especially at night. This review is about ways of reducing this problem and includes 15 trials containing 964 people, most of which were done in hospitals in China. Treatments included medications that had previously been useful for this problem or were thought to work in theory. The medications used were from a group of drugs called antimuscarinics, traditional Chinese medicines or others. The trials were short (all four weeks or less). From these trials the antimuscarinics; astemizole, diphenhydramine and propantheline, were shown to be better than placebo at reducing hypersalivation. Another medication called oryzanol and a Chinese traditional medicine called Suo quo wan were found to have benefit over doxepin, an antimuscarinic. However, because of the shortness of the trials, poor reporting and the limitations of design, it is difficult to draw any firm conclusions from these results. 

Use of clozapine in people with intellectual disabilities and psychoses

People with intellectual disability have a low score on intelligence tests. They have problems in areas like self‐care, social relationships, work, education and dealing with the challenges of daily life. To make a diagnosis of intellectual disability, we use tests in which we compare the performance of an individual person on certain tasks with other people of his or her age. People with intellectual disabilities are unable to process information as efficiently as people without intellectual disability. Depending on the severity of their condition, they need varying degrees of support to cope with the demands and expectations of life. Those who have a mild intellectual disability are able to manage their affairs with some additional support. Those who have a severe intellectual disability, most of the time are unable to live independently and require support on a daily basis.

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Summaries for consumers

Newer atypical antipsychotic medication versus clozapine for schizophrenia

Synopsis pending.

Interventions for people with schizophrenia who have too much saliva due to clozapine treatment

Clozapine is an antipsychotic medication used in the treatment of schizophrenia, a mental health problem that can cause symptoms such as hallucinations and delusions and social withdrawal. Clozapine may be useful in those for whom other medications have not worked very well. One of the common side‐effects of clozapine is having too much saliva in the mouth (hypersalivation). This can be embarrassing in public and problematic, especially at night. This review is about ways of reducing this problem and includes 15 trials containing 964 people, most of which were done in hospitals in China. Treatments included medications that had previously been useful for this problem or were thought to work in theory. The medications used were from a group of drugs called antimuscarinics, traditional Chinese medicines or others. The trials were short (all four weeks or less). From these trials the antimuscarinics; astemizole, diphenhydramine and propantheline, were shown to be better than placebo at reducing hypersalivation. Another medication called oryzanol and a Chinese traditional medicine called Suo quo wan were found to have benefit over doxepin, an antimuscarinic. However, because of the shortness of the trials, poor reporting and the limitations of design, it is difficult to draw any firm conclusions from these results. 

Use of clozapine in people with intellectual disabilities and psychoses

People with intellectual disability have a low score on intelligence tests. They have problems in areas like self‐care, social relationships, work, education and dealing with the challenges of daily life. To make a diagnosis of intellectual disability, we use tests in which we compare the performance of an individual person on certain tasks with other people of his or her age. People with intellectual disabilities are unable to process information as efficiently as people without intellectual disability. Depending on the severity of their condition, they need varying degrees of support to cope with the demands and expectations of life. Those who have a mild intellectual disability are able to manage their affairs with some additional support. Those who have a severe intellectual disability, most of the time are unable to live independently and require support on a daily basis.

See all (34)

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