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Cinacalcet (By mouth)

Lowers the amount of calcium in your blood.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Cinacalcet is used to treat hyperparathyroidism in patients with chronic kidney disease who are on dialysis. Hyperparathyroidism is a condition that is caused when the parathyroid glands located in the neck make too much parathyroid hormone (PTH). This hormone helps to control the concentrations of calcium and phosphorus in your blood. Cinacalcet lowers the amount of PTH which lowers the calciumRead more
Brand names include
Sensipar
Drug classes About this
Calcium Regulator

What works? Research summarized

Evidence reviews

Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients

Abnormal calcium and phosphorous levels in the blood and tissues occur in chronic kidney disease. These changes are linked to shorter survival and hardening of the arteries leading to heart disease. Standard therapy for abnormal calcium and other mineral levels includes dietary restrictions, phosphorous binders and vitamin D compounds. A newer treatment called cinacalcet showed promise for improving abnormal mineral levels but the effects of this drug on patient outcomes (the way patients feel function and survive) were unclear from early studies. We have updated an earlier review dated 2006 to include studies that assessed the effects of cinacalcet in about 7500 people with chronic kidney disease. While cinacalcet improves some blood abnormalities, it does not improve risk of death or heart disease in people treated with dialysis. In addition, people who take cinacalcet may experience increased nausea, vomiting and the need for blood tests to check blood calcium levels. The current research is high‐quality and means that additional new studies are unlikely to change our confidence in these results. Information for the use of cinacalcet in people with milder forms of kidney disease and those with a kidney transplant is insufficient to guide decision making.

The effectiveness and cost-effectiveness of cinacalcet for secondary hyperparathyroidism in end-stage renal disease patients on dialysis: a systematic review and economic evaluation

The parathyroids are four small glands found in the neck, close to the thyroid. Normally, homeostatic control of serum calcium and phosphate levels is regulated within narrow bounds through parathyroid hormone (PTH) released by the parathyroids. Secondary hyperparathyroidism (SHPT) is a common complication of end-stage renal disease (ESRD). It may develop early in chronic kidney disease (CKD) and progresses as renal function deteriorates. As it does so, the combined effects of reduced serum calcium, increased serum phosphate and decreased vitamin D activity lead to overactivity of the parathyroid glands as they try to maintain appropriate calcium levels. Eventually, the parathyroids may develop reduced expression of calcium and vitamin D receptors and so are less responsive to changes in serum levels that they should regulate.

Renal function in patients treated with cinacalcet for persistent hyperparathyroidism after kidney transplantation

BACKGROUND AND AIM: Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism (HPT) after kidney transplantation. We aimed to assess the association of cinacalcet with a decrease in renal function based on a meta-analysis of observational studies in kidney transplant patients with persistent HPT.

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Summaries for consumers

Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients

Abnormal calcium and phosphorous levels in the blood and tissues occur in chronic kidney disease. These changes are linked to shorter survival and hardening of the arteries leading to heart disease. Standard therapy for abnormal calcium and other mineral levels includes dietary restrictions, phosphorous binders and vitamin D compounds. A newer treatment called cinacalcet showed promise for improving abnormal mineral levels but the effects of this drug on patient outcomes (the way patients feel function and survive) were unclear from early studies. We have updated an earlier review dated 2006 to include studies that assessed the effects of cinacalcet in about 7500 people with chronic kidney disease. While cinacalcet improves some blood abnormalities, it does not improve risk of death or heart disease in people treated with dialysis. In addition, people who take cinacalcet may experience increased nausea, vomiting and the need for blood tests to check blood calcium levels. The current research is high‐quality and means that additional new studies are unlikely to change our confidence in these results. Information for the use of cinacalcet in people with milder forms of kidney disease and those with a kidney transplant is insufficient to guide decision making.

Etelcalcetide (Parsabiv) for the treatment of hyperparathyroidism (overactive parathyroid gland): Overview

Etelcalcetide (trade name: Parsabiv) has been approved in Germany since November 2016 for the treatment of secondary hyperparathyroidism (overactive parathyroid gland) in adults. It is an option for people with chronic kidney disease who are on dialysis.

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