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Micromedex DrugNotes [Internet]. Truven Health Analytics, an IBM company; 1974-2018.

Micromedex DrugNotes [Internet].

Chlorpromazine (Into the rectum)

Chlorpromazine (klor-PROE-ma-zeen)

Published: February 1, 2018.

Treats mental disorders, severe behavior disorders, severe hiccups, or severe nausea and vomiting. Belongs to a class of drugs called phenothiazines.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to chlorpromazine, or any other phenothiazine drug (such as Compazine®, or Mellaril®).

How to Use This Medicine


  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Never take rectal suppositories by mouth.
  • Wash your hands with soap and water before and after using this medicine. Remove the foil or wrapper from the suppository before inserting it.
  • Lie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch.
  • Keep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine applicator(s), containers, and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have asthma, emphysema, breast cancer, trouble urinating, glaucoma, seizures, or a bone marrow or blood disorder. Tell your doctor if you have heart, kidney, or liver disease, lupus, or if you are exposed to pesticides or extreme heat.
  • This medicine may cause drowsiness or affect your sight. Be careful when driving or using dangerous machinery.
  • There is a risk of side effects that include muscle spasms, twitching or trembling in your face and body, and uncontrolled tongue or jaw movement. Talk to your doctor about this risk.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

If you notice these less serious side effects, talk with your doctor:

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

© 2018 Truven Health Analytics LLC Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.


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