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Candesartan (By mouth)

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Candesartan is used alone or together with other medicines to treat high blood pressure (hypertension) in adults and children 1 to 16 years of age. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart Read more
Brand names include
Atacand
Drug classes About this
Antihypertensive, Cardiovascular Agent, Renal Protective Agent
Combinations including this drug

What works? Research summarized

Evidence reviews

A meta-analysis of the efficacy and safety of candesartan in Chinese patients with mild to moderate essential hypertension

Bibliographic details: Wen-Peng C, Bing D, Ling Q.  A meta-analysis of the efficacy and safety of candesartan in Chinese patients with mild to moderate essential hypertension. African Journal of Pharmacy and Pharmacology 2011; 5(8): 1012-1019 Available from: http://www.academicjournals.org/journal/AJPP/article-abstract/4D53DF131572

Comparison of the efficacy of candesartan and losartan: a meta-analysis of trials in the treatment of hypertension

This review found that candesartan was associated with significantly greater reductions in blood pressure in patients with hypertension compared with losartan. The results of this review should be interpreted with some caution, and the reliability of the authors' conclusions is uncertain due to the absence of a formal quality assessment and possible biases in the review process.

Comparative clinical- and cost-effectiveness of candesartan and losartan in the management of hypertension and heart failure: a systematic review, meta- and cost-utility analysis

The review found that candesartan appeared to reduce blood pressure slightly more than losartan, but that the difference may not be clinically significant. There was no good evidence that candesartan was superior to losartan for treating heart failure. These conclusions require some caution in interpretation due to limitations in the review, which included incomplete adherence to the inclusion criteria.

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Summaries for consumers

Choosing Medicines for High Blood Pressure: A Review of the Research on ACEIs, ARBs, and DRIs

You will learn what research says about three types of medicine for high blood pressure, how well they work, how they compare to each other, and their side effects. This information can help you talk with your doctor as you decide which ACEI, ARB, or DRI is best for you.

Medications for high blood pressure in children

This systematic review includes 21 trials, involving 3454 children, which evaluated different medications to lower blood pressure among children with hypertension. This evidence is up to date as of October 2013. Most trials were of very short duration with the average being seven weeks. The studies were of variable quality and mostly industry funded. Not all studies compared the effect of medication on blood pressure lowering to a placebo. Only a few classes of the commonly prescribed drugs have been evaluated and most had a modest effect on blood pressure, but it is uncertain whether this results in improved long‐term outcomes for children. Higher doses of medication did not result in greater reduction of blood pressure. All of the drugs studied were safe for use, at least in the short term.

Comparing ACE Inhibitors and related drugs

How do ACE inhibitors, AIIRAs, and DRIs compare in effectiveness?

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