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Bismuth Subsalicylate (By mouth)

Treats diarrhea, heartburn, nausea, and upset stomach. This medicine contains a salicylate and is related to aspirin.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Bismuth subsalicylate is used to treat diarrhea in adults and teenagers. It is also used to relieve the symptoms of an upset stomach, such as heartburn, indigestion, and nausea in adults and teenagers. This medicine is available without a prescription… Read more
Brand names include
Anti-Diarrheal, Bismatrol, Bismuth Extra Strength, Bismuth Original Formula, Compliments Bismuth - Regular Strength, Diotame, Diotame InstyDose, Diotame Stomach Relief, Geri-Pectate, Good Neighbor Pharmacy K-Pec, Good Neighbor Pharmacy Pink Bismuth, Good Neighbor Pharmacy Stomach Relief, Good Sense Stomach Relief, GoodSense Bismuth - Regular Strength, Health Mart Stomach Relief, Kao-Tin, Kaopectate, Kapectolin, Kola-Pectin, Peptic Relief, Pepto Bismol, Pepto Bismol Max, Pepto-Bismol, Stomach Relief - Regular Formula, Up & Up Bismuth - Regular Strength, Up & Up Extra Strength Bismuth
Drug classes About this
Antacid, Bismuth Containing, Antidiarrheal
Combinations including this drug

What works? Research summarized

Evidence reviews

Treatments for collagenous colitis

Collagenous colitis is a type of microscopic colitis, a condition characterized by chronic watery non‐bloody diarrhea. People with collagenous colitis have a normal appearing bowel when assessed by an endoscope (a camera used to look at the bowel); but have microscopic inflammation of the bowel when assessed by a biopsy (a tissue sample taken during endoscopy). The cause of this disorder is unknown.

Bismuth Salts for Gastrointestinal Issues: A Review of the Clinical Effectiveness and Guidelines [Internet]

The purpose of this report is to retrieve and review existing evidence of clinical efficacy, safety, and guidelines for bismuth treatment of diarrhea, nausea, indigestion, heartburn, and upset stomach. This report also aims to retrieve and review the existing evidence for the clinical efficacy and safety of bismuth as part of bismuth-containing quadruple therapy (BCQT) in the treatment of H. pylori infection. Finally this report will retrieve and review the existing guidelines on the use of BCQT for H. pylori eradication treatment.

Treatments for lymphocytic colitis

Lymphocytic colitis is a type of microscopic colitis, a condition characterized by chronic non‐bloody watery diarrhea. People with lymphocytic colitis have a normal appearing bowel when assessed by an endoscope (a camera used to look at the bowel) or an X‐ray; but have microscopic (histological) inflammation of the bowel when assessed by a biopsy (a tissue sample taken during endoscopy). The cause of this disorder is unknown. This review is an update of a previously published Cochrane review.

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Summaries for consumers

Treatments for collagenous colitis

Collagenous colitis is a type of microscopic colitis, a condition characterized by chronic watery non‐bloody diarrhea. People with collagenous colitis have a normal appearing bowel when assessed by an endoscope (a camera used to look at the bowel); but have microscopic inflammation of the bowel when assessed by a biopsy (a tissue sample taken during endoscopy). The cause of this disorder is unknown.

Treatments for lymphocytic colitis

Lymphocytic colitis is a type of microscopic colitis, a condition characterized by chronic non‐bloody watery diarrhea. People with lymphocytic colitis have a normal appearing bowel when assessed by an endoscope (a camera used to look at the bowel) or an X‐ray; but have microscopic (histological) inflammation of the bowel when assessed by a biopsy (a tissue sample taken during endoscopy). The cause of this disorder is unknown. This review is an update of a previously published Cochrane review.

Use of antimotility drugs (Loperamide, Diphenoxylate, Codeine) to control prolonged diarrhoea in people with HIV/AIDS.

People with HIV/AIDS often develop prolonged diarrhoea which are sometimes not caused by infections. This is more so in the sub‐Saharan Africa where drugs for controlling HIV itself i.e. antiretroviral drugs (ARV) may not be widely available or affordable. prolonged diarrhoea often results in prolonged illness and death due to loss of fluids, if not treated effectively and on time. Antimotility drugs and adsorbents are readily available and are used to try to control this condition while efforts are made to receive ARVs. We did not find enough evidence to support or refute their use in controlling this condition.

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