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Atracurium (By injection)

Relaxes muscles during surgery or other medical procedures.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Brand names include
Atracurium Besylate Novaplus, PremierPro RX atracurium besylate
Drug classes About this
Musculoskeletal Agent

What works? Research summarized

Evidence reviews

Techniques of intrauterine fetal transfusion for women with red‐cell isoimmunisation for improving health outcomes

Red‐cell alloimmunisation can occur when there are incompatibilities between a woman's blood type and that of her unborn baby (such as Rhesus or Kell). During pregnancy, the baby's blood can cross the placenta and enter the woman's circulation, which may cause her immune system to produce antibodies, that can then destroy the baby's red blood cells (haemolysis). This can cause the baby to become anaemic (have a low red blood cell count), and if severe, it may require a blood transfusion while the baby still remains within the uterus (called an intrauterine blood transfusion). This review of two randomised controlled trials, involving 44 pregnant women, found that there is currently insufficient information about the optimal technique for performing fetal intrauterine fetal blood transfusions. One of the studies compared two different muscle relaxants to keep the baby still during the procedure, and the other gave intrauterine fetal blood transfusions with and with intravenous immunoglobulin, without any clear differences.

Benefits and harms of sugammadex versus neostigmine in reversing induced paralysis

Different levels of induced paralysis are sometimes necessary when patients are put to sleep or are prepared for operations. When the operation is finished, paralysis should be reversed in a fast, reliable, and safe way. Neostigmine is a medication that is traditionally used to reverse induced paralysis. However, its use can be associated with incomplete or slow reversal as well as changes in lung function, heart function, and vomiting and nausea. Sugammadex is a relatively new medication specifically designed to reverse rocuronium‐induced paralysis in a faster, more reliable, and safer way when compared with neostigmine.

Neuromuscular Monitoring for Patients Receiving Continuous Paralytic or Neuromuscular Blocking Agents: A Review of the Clinical Effectiveness and Guidelines [Internet]

The purpose of this report is to review the clinical efficacy and the evidence-based guidelines regarding neuromuscular monitoring for guiding treatment and therapy for patients in the intensive care unit receiving continuous paralytic or neuromuscular blocking agents.

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Summaries for consumers

Techniques of intrauterine fetal transfusion for women with red‐cell isoimmunisation for improving health outcomes

Red‐cell alloimmunisation can occur when there are incompatibilities between a woman's blood type and that of her unborn baby (such as Rhesus or Kell). During pregnancy, the baby's blood can cross the placenta and enter the woman's circulation, which may cause her immune system to produce antibodies, that can then destroy the baby's red blood cells (haemolysis). This can cause the baby to become anaemic (have a low red blood cell count), and if severe, it may require a blood transfusion while the baby still remains within the uterus (called an intrauterine blood transfusion). This review of two randomised controlled trials, involving 44 pregnant women, found that there is currently insufficient information about the optimal technique for performing fetal intrauterine fetal blood transfusions. One of the studies compared two different muscle relaxants to keep the baby still during the procedure, and the other gave intrauterine fetal blood transfusions with and with intravenous immunoglobulin, without any clear differences.

Benefits and harms of sugammadex versus neostigmine in reversing induced paralysis

Different levels of induced paralysis are sometimes necessary when patients are put to sleep or are prepared for operations. When the operation is finished, paralysis should be reversed in a fast, reliable, and safe way. Neostigmine is a medication that is traditionally used to reverse induced paralysis. However, its use can be associated with incomplete or slow reversal as well as changes in lung function, heart function, and vomiting and nausea. Sugammadex is a relatively new medication specifically designed to reverse rocuronium‐induced paralysis in a faster, more reliable, and safer way when compared with neostigmine.

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