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What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Atomoxetine is used to treat attention-deficit hyperactivity disorder (ADHD) in children, teenagers, and adults. It belongs to the group of medicines called selective norepinephrine reuptake inhibitors. Atomoxetine works in the brain to increase attention and decrease restlessness in people who are hyperactive, have problems with concentration, or are easily distracted. This medicine may be used… Read more
Brand names include
Strattera
Drug classes About this
Central Nervous System Agent

What works? Research summarized

Evidence reviews

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

Attention deficit hyperactivity disorder (ADHD) (including hyperkinetic disorder) is defined by the 'core' signs of inattention, hyperactivity and impulsivity, and is characterised by an early onset. The estimated prevalence for ADHD in school-aged children varies widely (e.g. 3-7%), being dependent on a number of variables, including the methods of ascertainment, the informants, the population sampled, the diagnostic criteria applied and the sex of the affected individual. Data on prevalence in adolescence and adulthood are limited. The disorder is frequently observed in greater numbers of males than females, with ratios ranging from 2:1 to 9:1 depending on subtype and setting.

Drug treatments for chronic cognitive impairment in traumatic brain injury

Background: Traumatic brain injury (TBI) is a major cause of long‐term disability across the world. The disability is often related to chronic cognitive impairment, such as changes to memory, attention and problem solving.

Guanfacine Hydrochloride Extended Release (Intuniv XR) Tablets: For the Treatment of Attention-Deficit/Hyperactivity Disorder [Internet]

The objective of this review was to compare the clinical benefits and harms of guanfacine extended release (GXR; brand name: Intuniv XR) with those of other active treatments and placebo in children aged six to 12 years with attention-deficit/hyperactivity disorder (ADHD).

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Summaries for consumers

Drug treatments for chronic cognitive impairment in traumatic brain injury

Background: Traumatic brain injury (TBI) is a major cause of long‐term disability across the world. The disability is often related to chronic cognitive impairment, such as changes to memory, attention and problem solving.

Treatment Options for ADHD in Children and Teens: A Review of Research for Parents and Caregivers

This summary discusses the different types of treatment for ADHD. It explains what research says about how each treatment improves symptoms and the risks involved with each treatment. It can help you talk with the doctor about ADHD and your child.

Using selective noradrenaline reuptake inhibitors (NRIs) to treat schizophrenia

People with schizophrenia often have positive symptoms such as hearing voices (hallucinations), bizarre beliefs (delusions), or unclear thinking (formal thought disorder). These can be treated successfully with antipsychotic medication. People with schizophrenia also have negative symptoms such as social withdrawal or lack of motivation and cognitive symptoms such as difficulties making decisions and problems with attention or memory. Negative symptoms often are long term and reduce quality of life. Unlike the positive symptoms, there is a lack of effective medications to treat these negative symptoms.

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