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Aspirin Combination (By mouth)

Treats headache, minor pain, body aches, and drowsiness or tiredness.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Brand names include
Alka-Seltzer, Alka-Seltzer Extra Strength, Alka-Seltzer Morning Relief, Back & Body, Bayer Back & Body, Bayer Women's, Bc Headache Powder, Bc Powder Arthritis Strength, Bufferin, Bufferin Extra Strength, Equagesic, Goody's Fast Pain Relief, Medi-Seltzer, Ohmni-Cen, Pain Relief
Drug classes About this
Acetaminophen Combination, Acetaminophen/Salicylate, Aspirin Combination, Analgesic, Analgesic Combination, Salicylate, Antidote, Antipyretic, Antirheumatic, Platelet Aggregation Inhibitor, Salicylate, Aspirin Combination

What works? Research summarized

Evidence reviews

Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events

We reviewed the evidence about the effect of clopidogrel and aspirin in people at high risk of getting heart disease or having a stroke, and in those who already have heart disease.

Aspirin with or without an antiemetic for acute migraine headaches in adults

This is an updated version of the original Cochrane review published in Issue 4, 2010 (Kirthi 2010); no new studies were found. A single oral dose of 1000 mg of aspirin reduced pain from moderate or severe to none by two hours in approximately 1 in 4 people (24%) taking aspirin, compared with about 1 in 10 (11%) taking placebo. Pain was reduced from moderate or severe to no worse than mild pain by two hours in roughly 1 in 2 people (52%) taking aspirin compared with approximately 1 in 3 (32%) taking placebo. Of those who experienced effective headache relief at two hours, more had that relief sustained over 24 hours with aspirin than with placebo. Addition of 10 mg of the antiemetic metoclopramide substantially increased relief of nausea and vomiting compared with aspirin alone, but made little difference to pain.

Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia

Recurrent miscarriage is associated with inherited blood clotting disorders that could interfere with the placental blood circulation. Recurrent miscarriage can also be unexplained, with no known cause. Anticoagulant drugs such as aspirin or low molecular weight heparin may help women with recurrent miscarriage and such an underlying blood clotting problem. These drugs may also cause bleeding (including nose bleeds and haematomas) in the mother, though not in the baby. Data from nine included randomised controlled trials (involving 1228 women) analysed in this review, provided no evidence to support the use of anticoagulants in women with recurrent miscarriage, regardless of the presence of inherited blood clotting disorders (thrombophilia).

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Summaries for consumers

Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events

We reviewed the evidence about the effect of clopidogrel and aspirin in people at high risk of getting heart disease or having a stroke, and in those who already have heart disease.

Aspirin with or without an antiemetic for acute migraine headaches in adults

This is an updated version of the original Cochrane review published in Issue 4, 2010 (Kirthi 2010); no new studies were found. A single oral dose of 1000 mg of aspirin reduced pain from moderate or severe to none by two hours in approximately 1 in 4 people (24%) taking aspirin, compared with about 1 in 10 (11%) taking placebo. Pain was reduced from moderate or severe to no worse than mild pain by two hours in roughly 1 in 2 people (52%) taking aspirin compared with approximately 1 in 3 (32%) taking placebo. Of those who experienced effective headache relief at two hours, more had that relief sustained over 24 hours with aspirin than with placebo. Addition of 10 mg of the antiemetic metoclopramide substantially increased relief of nausea and vomiting compared with aspirin alone, but made little difference to pain.

Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia

Recurrent miscarriage is associated with inherited blood clotting disorders that could interfere with the placental blood circulation. Recurrent miscarriage can also be unexplained, with no known cause. Anticoagulant drugs such as aspirin or low molecular weight heparin may help women with recurrent miscarriage and such an underlying blood clotting problem. These drugs may also cause bleeding (including nose bleeds and haematomas) in the mother, though not in the baby. Data from nine included randomised controlled trials (involving 1228 women) analysed in this review, provided no evidence to support the use of anticoagulants in women with recurrent miscarriage, regardless of the presence of inherited blood clotting disorders (thrombophilia).

See all (52)

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