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Armodafinil (By mouth)

Treats sleepiness from narcolepsy, sleep apnea, or night shift work.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Armodafinil is used to help people who have narcolepsy, obstructive sleep apnea (also called hypopnea syndrome), or shift work sleep disorders to stay awake during the day. This medicine does not cure these conditions and will only work as long as you continue to take it. This medicine is available only with your doctor's prescription… Read more
Brand names include
Nuvigil
Drug classes About this
CNS Stimulant

What works? Research summarized

Evidence reviews

Drugs for treating people with sleepiness during shift work and sleep problems after shift work

People who work shifts often report sleepiness at work and problems with sleep between work shifts. This is called shift work sleep disorder when the difficulties with sleep after the night shift and sleepiness during the night shift are persistent. We evaluated the effect of drugs, such as melatonin, to improve shift workers' sleep quality after night shift work. We also examined the effect of drugs, such as caffeine, to help shift workers stay awake. We also wanted to evaluate cost‐effectiveness but there were no studies.

Pharmacological treatments for fatigue associated with advanced disease

In an advanced disease such as cancer, fatigue can be described as tiredness, weakness or lack of energy. Fatigue can affect daily activity and quality of life, and it is frequently reported by palliative care patients. The underlying causes of fatigue are not very well understood and fatigue is difficult to treat.

Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder [Internet]

To compare the benefits and harms of second-generation antidepressants (SGAs), psychological, complementary and alternative medicine, and exercise treatment options as first-step interventions for adult outpatients with acute-phase major depressive disorder (MDD), and as second-step interventions for patients with MDD who did not achieve remission after a first treatment attempt with SGAs.

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Summaries for consumers

Drugs for treating people with sleepiness during shift work and sleep problems after shift work

People who work shifts often report sleepiness at work and problems with sleep between work shifts. This is called shift work sleep disorder when the difficulties with sleep after the night shift and sleepiness during the night shift are persistent. We evaluated the effect of drugs, such as melatonin, to improve shift workers' sleep quality after night shift work. We also examined the effect of drugs, such as caffeine, to help shift workers stay awake. We also wanted to evaluate cost‐effectiveness but there were no studies.

Pharmacological treatments for fatigue associated with advanced disease

In an advanced disease such as cancer, fatigue can be described as tiredness, weakness or lack of energy. Fatigue can affect daily activity and quality of life, and it is frequently reported by palliative care patients. The underlying causes of fatigue are not very well understood and fatigue is difficult to treat.

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