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Ammonium Lactate (On the skin)

Treats dry, scaly skin from xerosis or ichthyosis. Also temporarily relieves itching caused by these conditions.

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Brand names include
AmLactin, Amlactin Distribution Pack, Geri-Hydrolac, Ultravate Pac
Drug classes About this
Antipruritic

What works? Research summarized

Evidence reviews

Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria

BACKGROUND: Irritable bowel syndrome (IBS) is a poorly understood, yet highly prevalent functional gastrointestinal disorder (FGID). The withdrawal, due to adverse events, of a number of pharmacological agents that were approved for the treatment of IBS has left a therapeutic vacuum for patients suffering from the disorder.

Meta analysis of lactic acid bacteria as probiotics for the primary prevention of infantile eczema

OBJECTIVE: To determine whether lactic acid bacteria as probiotics is efficacious in the primary prevention of infantile eczema or atopic eczema.

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration

People with acute kidney injury (AKI) have serious loss of kidney function and are unable to rid wastes from the body in urine. People with AKI need dialysis (haemofiltration) which requires use of buffered solutions (dialysates) to rid waste from their blood. Different dialysates can have various effects on the balance of blood chemistry. Maintaining balanced blood chemistry helps to reduce risks of heart, blood circulation and blood pressure problems. We assessed the benefits and harms of bicarbonate‐buffered solutions and lactate‐buffered solutions by analysing results from four randomised controlled studies that together involved 171 participants. The evidence was flawed by study design and reporting problems, and the small number of people in the studies. Based on limited evidence from one study (117 participants), we found that people treated with bicarbonate‐buffered solutions may experience fewer heart and blood circulation problems and high blood pressure events. The studies did not include enough evidence to make recommendations about the use of these solutions.

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Summaries for consumers

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration

People with acute kidney injury (AKI) have serious loss of kidney function and are unable to rid wastes from the body in urine. People with AKI need dialysis (haemofiltration) which requires use of buffered solutions (dialysates) to rid waste from their blood. Different dialysates can have various effects on the balance of blood chemistry. Maintaining balanced blood chemistry helps to reduce risks of heart, blood circulation and blood pressure problems. We assessed the benefits and harms of bicarbonate‐buffered solutions and lactate‐buffered solutions by analysing results from four randomised controlled studies that together involved 171 participants. The evidence was flawed by study design and reporting problems, and the small number of people in the studies. Based on limited evidence from one study (117 participants), we found that people treated with bicarbonate‐buffered solutions may experience fewer heart and blood circulation problems and high blood pressure events. The studies did not include enough evidence to make recommendations about the use of these solutions.

Which treatments are effective for bacterial vaginosis?

Bacterial vaginosis can cause symptoms such as discharge with an unpleasant odor. The antibiotics clindamycin and metronidazole are both effective treatments for bacterial vaginosis. There has not yet been enough research on the possible benefits of lactic acid bacteria treatments. Bacterial vaginosis is quite common and caused by changes in the vaginal flora that allow rapid growth of specific types of bacteria (usually Gardnerella). The infection can cause a thin, grayish-white discharge with an unpleasant odor, but it often goes undetected. If it does produce symptoms, antibiotics can be used as an effective treatment, also during pregnancy. Treatment can help lower the slightly increased risk of miscarriage due to the infection, too.

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus

Metformin, a medication used to lower glucose levels in patients with diabetes mellitus, has long been thought to increase the risk for a metabolic disorder known as lactic acidosis. This review summarised data from all known comparative and observational studies lasting at least one month, and found no cases of fatal or nonfatal lactic acidosis in 70,490 patient‐years of metformin use, or in 55,451 patient‐years for those not on metformin. Average lactate levels measured during metformin treatment were no different than for placebo or for other medications used to treat diabetes. In summary, there is no evidence at present that metformin is associated with an increased risk for lactic acidosis when prescribed under the study conditions.

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