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Voriconazole

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By mouth

Voriconazole is used to treat serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection… Read more

Brand names include: Vfend

By injection

Voriconazole injection is used to treat certain serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia… Read more

Brand names include: Amerinet Choice Vfend, PREMIERPro RX Vfend I.V.

Drug classes About this
Antifungal

What works? Research summarized

Evidence reviews

Is voriconazole better than amphotericin B or fluconazole to prevent and treat fungal infections in cancer patients with poor immune defence systems

Patients with cancer who are treated with chemotherapy or receive a bone marrow transplant have an increased risk of fungal infections. Such infections can be life‐threatening. Antifungal drugs are therefore often given to prevent fungal infections in such patients, either when these patients are known to have a fungal infection or when such an infection is suspected. We reviewed the evidence about the effect of voriconazole compared to amphotericin B or fluconazole to prevent or treat fungal infections in cancer patients with a poor immune system to provide defence.

Efficacy and safety of voriconazole in prophylaxis of invasive fungal infections: a meta-analysis

Bibliographic details: Li FF, Xu Y, Zhang X.  Efficacy and safety of voriconazole in prophylaxis of invasive fungal infections: a meta-analysis. Chinese Journal of Infection and Chemotherapy 2012; 12(6): 453-458 Available from: http://caod.oriprobe.com/articles/31368489/Efficacy_and_safety_of_voriconazole_in_prophylaxis_of_invasive_fungal_.htm

Medical treatments for fungal infection of the cornea (clear front part of the eye)

We identified 12 randomised controlled trials that included 981 people; the evidence is current up to March 2015. The trials were mainly conducted in India.

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Summaries for consumers

Is voriconazole better than amphotericin B or fluconazole to prevent and treat fungal infections in cancer patients with poor immune defence systems

Patients with cancer who are treated with chemotherapy or receive a bone marrow transplant have an increased risk of fungal infections. Such infections can be life‐threatening. Antifungal drugs are therefore often given to prevent fungal infections in such patients, either when these patients are known to have a fungal infection or when such an infection is suspected. We reviewed the evidence about the effect of voriconazole compared to amphotericin B or fluconazole to prevent or treat fungal infections in cancer patients with a poor immune system to provide defence.

Medical treatments for fungal infection of the cornea (clear front part of the eye)

We identified 12 randomised controlled trials that included 981 people; the evidence is current up to March 2015. The trials were mainly conducted in India.

Not enough good quality trials to assess the most effective drug treatment for paracoccidioidomycosis

Paracoccidioidomycosis is a fungal infection that causes ulcers, swelling, fever, and pain. If it also gets into the lungs, it can produce coughing, shortage of breath, chest pain, weight loss, and sometimes death. Without treatment, those suffering this disease may die in a few months or years. There are endemic areas between Mexico and southern Argentina. Drug treatments need to go on for many months and maybe years. There are various drugs that are used, but this review found only two small trials with too few data to say which drug was best, and the drugs all seem to have adverse effects. More research is needed.

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